Results 101 to 110 of about 5,798,177 (248)

Study of heat transfer through functionally graded material fins using analytical and numerical investigations

Curved and Layered Structures
The present study used analytical and numerical methods to conduction works in functional graded material fin that is exposed to progressive boundary cooling and heating.
Hussein Adnan A., Jabbar Nasr A., Ahmed Sahib S., Aljibori H. S. S., Mohammed M. N., Alturaihi Muna Hameed, Al-Ansari Luay S., Abdullah Oday I.   +7 more
doaj   +1 more source

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

Dynamic stress intensity factor of a functionally graded material under antiplane shear loading

, 2001
The dynamic response of a finite crack in an unbounded Functionally Graded Material (FGM) subjected to an antiplane shear loading is studied in this paper.
李春雨, 段祝平, Weng GJ, 邹振祝, Li, C (reprint author), Univ Delaware, Dept Mech Engn, Newark, DE 19716 USA.   +4 more
core   +1 more source

Microstructure and mechanical properties of Ti60–Ti2AlNb functionally graded materials fabricated by laser directed energy deposition

Journal of Materials Research and Technology
The increasing demands for materials that service under high temperature environments in advanced aero-engines with high thrust-to-weight ratios have led to the exploration of functionally graded materials, which can offer unique advantages for ...
Yaguang Wang, Shuai Liu, Yasong Tan, Meng Wang, Shufan Xian, Xueping Li, Qian Wang, Jiabao Guo, Xin Lin, Weidong Huang   +9 more
doaj   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Investigation of stress intensity factor for internal cracks in FG cylinders under static and dynamic loading

Fracture and Structural Integrity, 2016
This paper investigates the variations of mode I stress intensity factor (KI) for inner penny-shaped and circumferential cracks in functionally graded solid and hollow thick walled cylinders, respectively with the changes of crack geometry, material ...
Mahmoud Shariati, Masoud Mahdizadeh Rokhi, Hassan Rayegan   +2 more
doaj  

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Analytical model of functionally graded material/shape memory alloy composite cantilever beam under bending

, 2018
A new analytical model for a functionally graded material (FGM)/shape memory alloy (SMA) laminated composite cantilever beam subjected to a concentrated tip load is developed.
Zaki, W., Umer, R., Viet, N. V.
core   +1 more source

Research on Free Vibration Frequency Characteristics of Rotating Functionally Graded Material Truncated Conical Shells with Eccentric Functionally Graded Material Stringer and Ring Stiffeners

Latin American Journal of Solids and Structures
In this research work, an exact analytical solution for frequency characteristics of the free vibration of rotating functionally graded material (FGM) truncated conical shells reinforced by eccentric FGM stringers and rings has been investigated by the ...
Dao Van Dung, Hoang Thi Thiem
doaj   +1 more source