Results 141 to 150 of about 5,798,177 (248)

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

open access: yesFEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima   +8 more
wiley   +1 more source

IGF2 knockout reduces but does not abolish osteosarcoma growth in vitro and in vivo

open access: yesFEBS Open Bio, EarlyView.
To test whether endogenous IGF2 promotes osteosarcoma growth, IGF2 was knocked out in Saos2 cells via CRISPR‐Cas9. KO cells showed reduced proliferation in vitro, and knockout xenografts in mice reached only ~25% of wild‐type tumor volume. Insulin‐like growth factor 2 (IGF2) is implicated in osteosarcoma, but direct functional evidence of its role is ...
Shun Yao, Marco Archetti
wiley   +1 more source

Optimisation of material composition in functionally graded plates using a structure-tuned deep neural network

open access: yes
This study presents a neural network (NN)-based approach for optimising material composition in multi-layered functionally graded (FG) plates to minimise steady-state thermal stress.
Takuya Kishida   +3 more
core   +1 more source

FEM Simulations and Optimization about Residual Stresses in Coating Structures with Functionally Graded Materials Layer

open access: yes, 2003
An elasto-plastic finite element method is developed to predict the residual stresses of thermal spraying coatings with functionally graded material layer.
Huang CG(黄晨光)   +2 more
core   +1 more source

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