Results 51 to 60 of about 80,406 (296)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Microstructure and mechanical properties of Ti60–Ti2AlNb functionally graded materials fabricated by laser directed energy deposition

Journal of Materials Research and Technology
The increasing demands for materials that service under high temperature environments in advanced aero-engines with high thrust-to-weight ratios have led to the exploration of functionally graded materials, which can offer unique advantages for ...
Yaguang Wang, Shuai Liu, Yasong Tan, Meng Wang, Shufan Xian, Xueping Li, Qian Wang, Jiabao Guo, Xin Lin, Weidong Huang   +9 more
doaj   +1 more source

Corrosion Behavior of (Copper/Nickel) step-wise Functionally Graded Materials [PDF]

Archives of Foundry Engineering
The present paper involves studying of the corrosion behaviour of five layers Cu/Ni Functionally Graded Materials (FGMs) in a 3.5 % NaCl solution to examine corrosion potentials (Ecorr.), corrosion current densities (icorr.) and Tafel slope. Three series
Dheya Abdulamer, Noor Sh Ghafil, Dhuha Albusalih, Alaa Abdulhasan Atiyah   +3 more
doaj   +1 more source

Application of functionally graded materials for severe plastic deformation and smart materials: experimental study and finite element analysis [PDF]

, 2012
Functionally graded materials (FGMs) refer to the composite materials where the compositions or the microstructures are locally varied so that a certain variation of the local material properties is achieved.
Jamian, Saifulnizan
core  

Gradient design of metal hollow sphere (MHS) foams with density gradients [PDF]

, 2012
This is the post-print version of the final paper published in Composites Part B: Engineering. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural ...
Liu, Y, Wang, B, Wu, H-X
core   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

Multi-Material Ultrasonic Consolidation [PDF]

, 2006
Ultrasonic consolidation (UC) is a recently developed direct metal solid freeform fabrication process. While the process has been well-demonstrated for part fabrication in Al alloy 3003 H18, including with intricate cooling channels, some of the ...
Janaki Ram, G. D., Robinson, C., Stucker, B. E.   +2 more
core   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Design and Analysis of Porous Functionally Graded Femoral Prostheses with Improved Stress Shielding

Designs, 2020
One of the most important problems of total hip replacement is aseptic loosening of the femoral component, which is related to the changes of the stress distribution pattern after implantation of the prosthesis.
Morassa Jafari Chashmi, Alireza Fathi, Masoud Shirzad, Ramazan-Ali Jafari-Talookolaei, Mahdi Bodaghi, Sayed Mahmood Rabiee   +5 more
doaj   +1 more source

3D hybrid wound devices for spatiotemporally controlled release kinetics [PDF]

, 2012
This paper presents localized and temporal control of releasekinetics over 3-dimensional (3D) hybridwounddevices to improve wound-healing process. Imaging study is performed to extract wound bed geometry in 3D.
Koc, Bahattin, Koç, Bahattin, Ozbolat, Ibrahim T., Özbolat, İbrahim T.   +3 more
core   +1 more source