Results 51 to 60 of about 79,751 (296)

Free vibrations and static analysis of functionally graded sandwich plates with three-dimensional finite elements [PDF]

, 2020
A three-dimensional modelling of free vibrations and static response of functionally graded material (FGM) sandwich plates is presented. Natural frequencies and associated mode shapes as well as displacements and stresses are determined by using the ...
Burlayenko, V. N., Sadowski, Tomasz
core  

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Microstructure and mechanical properties of Ti60–Ti2AlNb functionally graded materials fabricated by laser directed energy deposition

Journal of Materials Research and Technology
The increasing demands for materials that service under high temperature environments in advanced aero-engines with high thrust-to-weight ratios have led to the exploration of functionally graded materials, which can offer unique advantages for ...
Yaguang Wang, Shuai Liu, Yasong Tan, Meng Wang, Shufan Xian, Xueping Li, Qian Wang, Jiabao Guo, Xin Lin, Weidong Huang   +9 more
doaj   +1 more source

Characterization of functionally graded Al-SiCp metal matrix composites manufactured by centrifugal casting

Alexandria Engineering Journal, 2017
The design of metal matrix composites can be enhanced by integrating the concept of functionally graded materials (FGM) to produce engineering materials with tailored contradictory properties that suit multifunctioning components.
I.M. El-Galy, M.H. Ahmed, B.I. Bassiouny
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Homemade yeast by using tropical fruits through fermentation process [PDF]

, 2020
Yeast is one type of bacteria that is used in baking industry and as the crucial parameters to determine the softness of the bread. Many tropical fruits can be used as a medium to produce yeast. The main goal of this study is to produce homemade yeast by
Abdul Rahman, Misbahul Muneer, Che Kamaruddin, Aminul Hakim, Sani, Husna Izzati, Zolkifli, Nur Athirah   +3 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Effects of thickness stretching in functionally graded plates and shells

, 2011
1The present work evaluates the effect of thickness stretching in plate/shell structures made by materials which are functionally graded (FGM) in the thickness directions.
Batra, Bayat, Birman, Brischetto, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Carrera, Cauchy, Chi, Chi, Chiba, Estili, Ferreira, Haddadpour, Kashtalyan, Kashtalyan, Kirchhoff, Koizumi, Koizumi, Mindlin, Mori, Na, Pagano, Pagano, Pan, Poisson, Qian, Ramirez, Reissner, Vel, Vel, Zenkour   +37 more
core   +1 more source

3D hybrid wound devices for spatiotemporally controlled release kinetics [PDF]

, 2012
This paper presents localized and temporal control of releasekinetics over 3-dimensional (3D) hybridwounddevices to improve wound-healing process. Imaging study is performed to extract wound bed geometry in 3D.
Koc, Bahattin, Koç, Bahattin, Ozbolat, Ibrahim T., Özbolat, İbrahim T.   +3 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source