Results 71 to 80 of about 42,232 (281)

Bending and vibration of functionally graded material sandwich plates using an accurate theory

, 2012
In this paper, the bending and the free flexural vibration behaviour of sandwich functionally graded material (FGM) plates are investigated using QUAD-8 shear flexible element developed based on higher order structural theory.
Ali, Anderson, Bhangale, Das, Ferreira, Ganapathi, Ganapathi Manickam, Koizumi, Li, Makhecha, Murukami, Natarajan, Nosier, Pan, Reddy, Roderigues, S. Natarajan, Shen, Singh, Vel, Zenkour, Zenkour   +21 more
core   +1 more source

Assessing plantar sensation in the foot using the FOot Roughness Discrimination Test (FoRDT™): a reliability and validity study in stroke [PDF]

, 2019
BACKGROUND: The foot sole represents a sensory dynamometric map and is essential for balance and gait control. Sensory impairments are common, yet often difficult to quantify in neurological conditions, particularly stroke.
Bi J, Bland M, Bolognin N, Carey L, Carey LM, Cohen J, Doros G, Eckstrand E   +7 more
core   +3 more sources

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Navier Solution for Buckling Analysis of Size-Dependent Functionally Graded Micro-Plates

Latin American Journal of Solids and Structures
In the present paper, buckling analysis of functionally graded rectangular micro-plates, on the basis of strain gradient theory with one length scale parameter is studied.
H. Farahmand, S. S. Naseralavi, A. Iranmanesh, M. Mohammadi   +3 more
doaj   +1 more source

Design of a Functionally Graded Material Phonon Crystal Plate and Its Application in a Bridge

Applied Sciences, 2023
In order to alleviate the structural vibrations induced by traffic loads, in this paper, a phonon crystal plate with functionally graded materials is designed based on local resonance theory.
Shuqin Li, Jing Song, Jingshun Ren
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Refined shell elements for the analysis of functionally graded structures [PDF]

, 2011
The present paper considers the static analysis of plates and shells made of Functionally Graded Material (FGM), subjected to mechanical loads. Refined models based on the Carrera's Unified Formulation (CUF) are employed to account for grading ...
Carrera, Erasmo, Chinosi, C., Cinefra, Maria, Della Croce, L.   +3 more
core   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source