Results 81 to 90 of about 42,232 (281)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

3D thermally induced analysis of annular plates of functionally graded materials

Theoretical and Applied Mechanics Letters, 2019
Within the framework of three-dimensional elasticity theory, this paper investigates the thermal response of functionally graded annular plates in which the material can be transversely isotropic and vary along the thickness direction in an arbitrary ...
Yun-Fang Yang, Ding Chen, Bo Yang
doaj   +1 more source

Static and Dynamic Thermomechanical Buckling Loads of Functionally Graded Plates. [PDF]

, 2013
In the paper the buckling phenomenon for static and dynamic loading (pulse of finite duration) of FGM plates subjected to simultaneous action of one directional compression and thermal field is presented.
Kowal-Michalska, Katarzyna, Mania, Radosław J.   +1 more
core  

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Vibration Characteristic Analysis of Sandwich Composite Plate Reinforced by Functionally Graded Carbon Nanotube-Reinforced Composite on Winkler/Pasternak Foundation

Journal of Marine Science and Engineering
This paper presents numerical investigations into the free vibration properties of a sandwich composite plate with two fiber-reinforced plastic (FRP) face sheets and a functionally graded carbon nanotube-reinforced composite (FG-CNTRC) core made of ...
Mengzhen Li, Xiaolong Liu, Mohammad Yazdi, Wei Chen   +3 more
doaj   +1 more source

Thermal buckling of imperfect functionally graded plates

International Journal of Solids and Structures, 2006
AbstractThermal buckling analysis of rectangular functionally graded plates (FGPs) with geometrical imperfections is presented in this paper. The equilibrium, stability, and compatibility equations of an imperfect functionally graded plate are derived using the classical plate theory.
Samsam Shariat, B.A., Eslami, M.R.
openaire   +1 more source

State-space Levy solution for size-dependent static, free vibration and buckling behaviours of functionally graded sandwich plates [PDF]

, 2018
The size-dependent static, free vibration and buckling behaviours of functionally graded (FG) sandwich plates are analysed in this study. Utilising the modified couple stress theory and variational principle, governing equations of motion are developed ...
Nguyen, Kien, Poologanathan, Keerthan, Thai, Tai, Trinh, Luan, Vo, Thuc   +4 more
core   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Development of a Co-Cr-Mo to Tantalum Transition using LENS for Orthopedic Applications [PDF]

, 2005
Biomedical implant material research using additive manufacturing is a popular field of study. Many potential material combinations exist which, if implemented properly, could have a significantly positive effect on implant life and functionality.
Kumar, Saripella Surya, Stucker, Brent
core   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source