Results 41 to 50 of about 2,700 (218)

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Vibrations Evaluation of Functionally Graded Porous Beams in Thermal Surroundings by Generalized Differential Quadrature Method

Shock and Vibration, 2022
This study investigates how to obtain the natural frequency of functionally graded porous beams simply supported on an elastic substrate in thermal surroundings by the theory of third-order shear deformation.
Mahdi Khakpour, Yousef Bazargan-Lari, Parham Zahedinejad, Mohammad- Javad Kazemzadeh-parsi   +3 more
doaj   +1 more source

Mechanical behavior of 2D FGP beam with uneven porosity distribution

Journal of Architectural and Engineering Research, 2023
This study gives the mechanical behavior of 2D functionally graded porous (FGP) beams using the finite element method. The Matlab code with simple Timoshenko beam elements is written to solve 2D FGP beam problems under distributed load.
Lan Hoang That Ton
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Functionally graded porous material and its application in sandwich beams for bending and vibration behaviors [PDF]

Computer Methods in Materials Science
The article describes a functionally graded porous material in an application for sandwich beams. The bending and vibration behaviors of this structure are studied using the finite element method based on a simple beam model.
Lan Hoang Ton That
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Thermal Prediction of Convective-Radiative Porous Fin Heatsink of Functionally Graded Material Using Adomian Decomposition Method

Computation, 2019
In recent times, the subject of effective cooling have become an interesting research topic for electronic and mechanical engineers due to the increased miniaturization trend in modern electronic systems.
George Oguntala, Gbeminiyi Sobamowo, Yinusa Ahmed, Raed Abd-Alhameed   +3 more
doaj   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source

Investigation of Fracture Mechanism and Mechanical Properties for Functionally Graded Porous Materials: A Review

Anbar Journal of Engineering Sciences
This review presents a comprehensive study of recent advances in the fracture behavior of functionally graded porous materials (FGPMs), with a specific focus on application, fracture mechanism, and mechanical characteristics.
Sama Omar, Ghalib Rzayyig Ibrahim
doaj   +1 more source