Results 181 to 190 of about 1,556,466 (314)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Exploring Subpopulations for Epidemiological Precision Nutrition Research: The Example of <i>Phenylalanine Hydroxylase (PAH)</i> Genetic Variation. [PDF]

Nutrients
Dhawan A, Khan SM, Fennell ML, Cho CE, Monk JM, Keathley JR.   +5 more
europepmc   +1 more source

Utility of the International Classification of Functioning, Disability and Health (ICF) for educational psychologists’ work

, 2014
Despite embracing a bio-psycho-social perspective, the World Health Organization’s International Classification of Functioning, Disability and Health (ICF) assessment framework has had limited application to date with children who have special ...
Frederickson, N, Aljunied, M
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Factors associated with social functioning by relapse frequency in Japanese outpatients with schizophrenia: the Multicenter Treatment Survey and Assessments for Schizophrenia in Psychiatric Clinics (MUSASI). [PDF]

Psychol Med
Takekita Y, Katsumoto E, Adachi N, Kubota Y, Edagawa K, Azekawa T, Ueda H, Tamura T, Hongo S, Goto E, Hida H, Miki K, Fujii C, Watanabe K, Kato M, Yasui-Furukori N, Takeuchi H.   +16 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Cognitive Functioning After Circulatory Shock: A Prospective Observational Study. [PDF]

Acta Anaesthesiol Scand
Laurila S, Nordenswan E, Ollila H, Pihlaja R, Wilkman E, Varis E, Heliste M, Koskinen S, Tuulio-Henriksson A, Tiainen M, Huhtala H, Kuitunen AH, Hokkanen L, Hästbacka J.   +13 more
europepmc   +1 more source

Family profiles in eating disorders: family functioning and psychopathology

, 2017
Luca Cerniglia,1 Silvia Cimino,2 Mimma Tafà,2 Eleonora Marzilli,2 Giulia Ballarotto,2 Fabrizia Bracaglia2 1Faculty of Psychology, International Telematic University UNINETTUNO, 2Department of Dynamic and Clinical Psychology, University of Rome ...
Marzilli E, Cerniglia L, Tafà M, Ballarotto G, Bracaglia F, Cimino S   +5 more
core  

Lipschitz functions of continuous functions [PDF]

Pacific Journal of Mathematics, 1953
Marx, Imanuel, Piranian, George
openaire   +3 more sources