Results 121 to 130 of about 426,019 (285)

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

The Community Satisfaction Analysis in Mangrove Forests Management in the Unit X KPHL Batu Bara Using Importance Performance Analysis

Jurnal Ilmu Kehutanan
Sustainable forest management encompasses a holistic approach that considers forests' ecological, social, and economic functions. However, an increasing focus on economic functions often leads to the neglect of social and ecological aspects. Consequently,
Eva Maria Natalina Ginting, Anita Zaitunah, OK Hasnanda Syahputra   +2 more
doaj   +1 more source

Function-as-a-Service Allocation Policies Made Formal

Function-as-a-Service (FaaS) is a Serverless Cloud paradigm where a platform manages the execution scheduling (e.g., resource allocation, runtime environments) of stateless functions. Recent developments demonstrate the benefits of using domain-specific languages to express per-function scheduling policies, e.g., enforcing the allocation of functions ...
Palma, Giuseppe De, Giallorenzo, Saverio, Mauro, Jacopo, Trentin, Matteo, Zavattaro, Gianluigi   +4 more
openaire   +3 more sources

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Function-as-a-Service on Kubernetes using Knative

, 2019
The CERN Cloud Infrastructure team provides compute resources as a service to teams across CERN. Users can provision resources to process experiment data, host web applications, and accomplish other computing tasks. The CERN cloud is built using OpenStack, an open-source suite of technologies for provisioning and managing a variety of computing ...
openaire   +1 more source

Analysis of Continuous Traffic Flow of Commercial Zones [PDF]

, 2019
Bandar Lampung city is an activity center that functions as a service, production, and distribution of goods as well as the entrance or knot of transportation for the surrounding area.
Anggraini, Dian, Hidayat, Aditya Mahatidanar, Kristin, Tiara Noviri   +2 more
core   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

FunLess: Functions-as-a-Service for Private Edge Cloud Systems

We present FunLess, a Function-as-a-Service (FaaS) platform tailored for the private edge cloud system. FunLess responds to recent trends that advocate for extending the coverage of serverless computing to private edge cloud systems and enhancing latency,
De Palma, Giuseppe, Giallorenzo, Saverio, Mauro, Jacopo, Trentin, Matteo, Zavattaro, Gianluigi   +4 more
core  

Next‐generation proteomics improves lung cancer risk prediction

Molecular Oncology, EarlyView.
This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj, Clara Frick, Ben Schöttker, Bernd Holleczek, Hermann Brenner   +4 more
wiley   +1 more source