Results 261 to 270 of about 5,311,244 (314)

The failure of the Ehlers-Kundt conjecture in the impulsive case. [PDF]

Gen Relativ Gravit
Frauenberger ML, Grant JDE, Steinbauer R.   +2 more
europepmc   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Fc effector functions in RNA viral infections: mechanisms of antiviral immunity and implications for vaccine design. [PDF]

Front Immunol
Zhang J, Li C, Wu Y, Wang L, Yu J, Wang A, Kong W, Ning M, Chen J, Chen Y.   +9 more
europepmc   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Functional redundancy as a stabilizing principle in bacterial communities under antibiotic perturbation: mechanisms, trade-offs, and emerging frameworks. [PDF]

Front Med (Lausanne)
Ge J.
europepmc   +1 more source

Identification of International Classification of Functioning, Disability and Health (ICF) codes most frequently used to describe functioning in children: a systematic review. [PDF]

BMJ Paediatr Open
Santos Vieira Lisboa Bordalo IM, Pereira CM, Fonseca C, Bico I.   +3 more
europepmc   +1 more source

Whole-to-parts causation mechanism. [PDF]

Front Psychol
Ohmura Y, Kuniyoshi Y.
europepmc   +1 more source

On the Open TS/ST Correspondence. [PDF]

Commun Math Phys
François M, Grassi A.
europepmc   +1 more source