Results 121 to 130 of about 6,178,348 (299)

Function beyond function? Reflections on the functionality of the autonomous

De Musica Disserenda, 2006
Of all the arts, music has always seemed to be the most autonomous, free from the bonds and limits of representation. Hence its functionality within this very autonomy or non-functionality: its link with the sacred, elevation over the economics of survival, its ritual value.
openaire   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Intravitreal Ranibizumab versus Vitreous Lavage for Postoperative Vitreous Hemorrhage in Proliferative Diabetic Retinopathy: A Randomized Controlled Trial

Drug Design, Development and Therapy
Jiaxing Chi,1,* Xiang Zhang,1,* Zetong Nie,1 Yue Pan,1 Wenbo Li,1 Bojie Hu2 1Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of ...
Chi J, Zhang X, Nie Z, Pan Y, Li W, Hu B
doaj  

TRUTH-FUNCTIONALITY

The Review of Symbolic Logic, 2008
It is shown that the standard definitions of truth-functionality, though useful for their purposes, ignore some aspects of the usual informal characterisations of truth-functionality. An alternative definition is given that results in a stronger notion that pays attention to those aspects.
openaire   +4 more sources

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A New Indole Derivative, LWX-473, Overcomes Glucocorticoid Resistance in Jurkat Cells by Activating Mediators of Apoptosis

Frontiers in Bioscience-Landmark
Background: Glucocorticoids (GCs) are commonly used as the primary chemotherapy for lymphoid malignancies, including acute lymphoblastic leukemia (ALL). However, the development of GC resistance limits their prolonged use.
Jingrui Song, Kun Yang, Babu Gajendran, Krishnapriya M. Varier, Wenxue Li, Qin Liu, Qing Rao, Yubing Hang, Xiangchun Shen, Sheng Liu, Lei Huang, Mei Xu, Yanmei Li   +12 more
doaj   +1 more source

Spatial Function-on-Function Regression

Journal of Agricultural, Biological and Environmental Statistics
43 pages, 6 figures, 3 ...
Ufuk Beyaztas, Han Lin Shang, Gizel Bakicierler Sezer, Abhijit Mandal, Roger S. Zoh, Carmen D. Tekwe   +5 more
openaire   +2 more sources