Results 81 to 90 of about 3,409,433 (269)
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Selective ERK1/2 agonists isolated from Melia azedarach with potent anti-leukemic activity
BMC Cancer, 2019 Background MAPK/ERK kinases transmit signals from many growth factors/kinase receptors during normal cell growth/differentiation, and their dysregulation is a hallmark of diverse types of cancers.
Ning Wang +11 more
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Functionals on continuous functions [PDF]
Pacific Journal of Mathematics, 1974 Baxter, J. R., Chacon, R. V.
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Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Synthesis of Flavone Derivatives via N-Amination and Evaluation of Their Anticancer Activities
Molecules, 2019 Seventeen new flavone derivatives substituted at the 4′-OH position were designed, synthesized and evaluated for their anticancer and antibacterial activities.
Ni Zhang +7 more
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Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Symmetric Functions, Noncommutative Symmetric Functions And Quasisymmetric Functions II
Acta Applicandae Mathematicae, 2003 This is part two of this survey; to appear in Acta. Appl. Math. The first part appeared in Acta Appl. Math 75 (2003), 55-93 and is also 'arXived'.
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FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Advances in Oral and Maxillofacial SurgeryPurpose: This study aimed to analyse the relationship between changes in the anterior nasal cavity volume and nasal airway resistance following posterosuperior movement of the maxilla. Materials and methods: We studied 16 patients (13 female, 3 male) who
Jing Yuan +5 more
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