Results 211 to 220 of about 6,413,720 (299)

From Static Choices to Navigating Clinical Trajectories: Reframing Therapeutic Reasoning in Medical Education. [PDF]

J Eval Clin Pract
von Kodolitsch Y, Dreyer T, Wick T, Harendza S.   +3 more
europepmc   +1 more source

Soft motions encoded by the fold and mediated by conserved hinge sites drive V‐ATPase allosteric machinery and autoinhibition

FEBS Letters, EarlyView.
Vacuolar H+‐ATPase (V‐ATPase) is a multisubunit rotary proton pump that acidifies intracellular compartments. Using elastic network models, we identified conserved hinge residues that govern its large‐scale functional motions. We show that intrinsically encoded ‘soft modes’ drive critical functional transitions, including rotary catalysis and ...
Diksha Parwana, Xiaowei Bogetti, Stuti Sharma, Ivet Bahar   +3 more
wiley   +1 more source

Nucleoporins in Cancer: Functional Roles and Therapeutic Opportunities. [PDF]

Cancer Discov
Kirthika P, Jawalagatti V, Carceles-Cordon M, Domingo-Domenech J, Rodriguez-Bravo V.   +4 more
europepmc   +1 more source

Unlocking the potential of cell‐permeable nanobodies for intracellular applications

FEBS Letters, EarlyView.
This review outlines current strategies for delivery of nanobodies into cells and highlights recent examples of functional applications. By addressing and manipulating intracellular targets, these molecules hold great potential for treating cancer, respiratory diseases and neurological disorders, making this a vibrant area of research in the biomedical
Mariona Gené‐Verdés, Luise Franz, Christian P.R. Hackenberger   +2 more
wiley   +1 more source

Executive Functions Among Kindergarteners in the Capital of Laos: Relations with Socialization Practices and Later Mathematics Skills. [PDF]

Dev Sci
Kajiyama Y, Takahashi Y, Moriguchi Y.
europepmc   +1 more source

Synthesis and Antitumor Activity of 6‑(2-Aminobenzo[d]thiazol-5-yl) quinazolin-4(3H)‑one Derivatives

ACS Omega
Ailing Linghu, Lei Tang, Qing Li, Ting Zhong, Fang Luo, Xinran Zhao, Feng Zhang, Mingzhi Su, Yanhua Fan, Linzhen Li   +9 more
doaj   +1 more source

Comparing the paths of Hedgehog release in artificial and natural settings

FEBS Letters, EarlyView.
Hh morphogens require solubilization factors to overcome their tight association with the plasma membrane and signal to distant cells, but the precise functions of these factors are controversial. Here, we use published in vivo observations as the most relevant evidence to test their suggested functions and discuss contradictions and gaps between in ...
Janna Puschmann, Kay Grobe
wiley   +1 more source

Rethinking the Oligodendrocyte Progenitor Cell: One Cell, Many Functions. [PDF]

Eur J Neurosci
de la Fuente AG.
europepmc   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

What can functional transcranial Doppler ultrasonography reveal about the cerebral lateralization of writing

FEBS Letters, EarlyView.
Which brain hemisphere controls writing? This review synthesizes all five functional transcranial Doppler studies of writing (handwriting and typing) published to date in adults and children. Right‐handers show left‐hemispheric dominance for the linguistic component of writing (written word generation), whereas findings for left‐handers remain ...
Marietta Papadatou‐Pastou
wiley   +1 more source