Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
FEBS Letters, EarlyView.Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante +10 more
wiley +1 more source
Variation in Clinical Teaching Fellow Programmes: Problem or Insight? [PDF]
Clin TeachJones N, Khan Z, Hofmann R.
europepmc +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Reframing Antimicrobial Stewardship as Systems Governance: Aligning Regulation, Diagnostics, Antibiotic Use Measurement, and Surveillance to Address Antimicrobial Resistance. [PDF]
Antibiotics (Basel)Mayi B, Dharmapalan D, Shet A.
europepmc +1 more source
Lipschitz functions of continuous functions [PDF]
Pacific Journal of Mathematics, 1953 Marx, Imanuel, Piranian, George
openaire +3 more sources
Subclasses of Analytic Functions Defined by Carlson - Shaffer Linear Operator
, 2015 [[abstract]]We introduce the subclass LT (a, c; , ) of analytic functions with negative coefficients defined by the linear operator L(a, c)f(z) which introduced and studied by Carlson and Shaffer [4].
B. A. Frasin
core
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
Potential Indicators of Transition to Cognitive Decline in Older Men: A Longitudinal Analysis of Multiple Sensory, Balance, and Gait Changes. [PDF]
Diagnostics (Basel)Yoon J, Kwak K, Kim D.
europepmc +1 more source