Results 111 to 120 of about 29,967 (292)

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Rate of convergence of Stancu beta operators for functions of bounded variation

Journal of Numerical Analysis and Approximation Theory, 2004
In this paper we study beta operators of second kind recently introduced by Prof. D. D. Stancu. We obtain an estimate on the rate of convergence for functions of bounded variation by means of the decomposition technique.
Ulrich Abel, Vijay Gupta
doaj   +2 more sources

On the derivatives of functions of bounded variation

, 2000
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +3 more sources

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Weighted fractional Euler–Maclaurin inequalities for convex and bounded variation functions via Riemann–Liouville integrals

Journal of Inequalities and Applications
This paper develops weighted Euler–Maclaurin-type inequalities using Riemann–Liouville fractional integrals for classes of differentiable convex functions and functions of bounded variation.
Areej A. Almoneef, Abd-Allah Hyder, Fatih Hezenci, Hüseyin Budak   +3 more
doaj   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

A duality theorem by means of Riemann Stieltjes integral

Le Matematiche, 1993
Duality between the space of continuous functions and the space of bounded variations functions can be easily characterized by means of Riemann-Stieltjes integrals when we consider real valued functions defined, e.g., on [0,1]; here we give a self ...
Ottavio Caligaris, Pietro Oliva
doaj  

A Generalized and Refined Perturbed Version of Ostrowski Type Inequalities

International Journal of Analysis and Applications, 2017
In this paper, we first obtain a new identity for twice differentiable mappings. Then, we establish generalized and improved perturbed version of Ostrowski type inequalities for functions whose derivatives are of bounded variation or second derivatives ...
M. Z. Sarikaya, H. Budak, S. Erden, A. Qayyum   +3 more
doaj   +2 more sources