Results 111 to 120 of about 4,360,675 (386)

The role of histone modifications in transcription regulation upon DNA damage

open access: yesFEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

A discrete martingale model of pension fund guarantees in [PDF]

open access: yes
In this paper we present a solution to the problem of pricing guarantees of minimum returns on pension fund contributions. These guarantees exist by law in Colombia and cover all pension fund contributions made to the country's private pension fund ...
Klaus P. Fischer
core  

Obama Administration FY 2015 Budget Proposal: Sustainable Energy, Buildings, Transportation and Climate [PDF]

open access: yes, 2014
President Obama released his $3.9 trillion fiscal year (FY) 2015 budget proposal for the federal government on March 4, 2014. The budget reflects the administration's "all of the above" energy strategy as well as its reinvigorated focus on addressing ...

core  

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Experiments to Enhance Public Real Estate in Italy: the Case of the FIP Fund

open access: yesTechne, 2012
The Italian State’s real estate is involved in a boundary definition process which is still in progress. The experiments in process and the comparison between Public Administration and private operators often focus the debate on issues which relate to ...
Andrea Ciaramella
doaj   +1 more source

Program Alokasi Dana Desa (Add) Dalam Pengembangan Ekonomi Di Kecamatan Marawola Kabupaten Sigi [PDF]

open access: yes, 2016
This research intends to find out and analyze: 1) planning process, action, eveluation, and accountability of the village fund at Marawola district , Sigi regency; and 2) village allocation funds program in economic development at Marawola district ...
Nasar, M. (M)
core  

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

Quick Response Funds and DRRM Resources in the Department of National Defense and Various Departments [PDF]

open access: yes, 2014
The study assesses the process of quick response fund (QRF) allocation, administration, and implementation under the various executive departments with cognizance of national disaster risk reduction management (DRRM) imperatives.
Domingo, Sonny N.
core  

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