Results 111 to 120 of about 727,497 (306)

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

(Fund)raising honors: Blending conventional and technological approaches to development

Journal of the European Honors Council, 2020
Rebecca Bott-Knutson, Hanna Holmquist, Keith Mahlum   +2 more
doaj   +1 more source

Managing reputation for ‘good works’ while undertaking commercial activities: Communication best practice guidelines for charities [PDF]

, 2010
Charities and not-for-profit organisations have traditionally eschewed commercial operations in favour of direct fund-raising from supporters. Competitive pressures, however, are driving charities to take on ‘dual citizenship’ through activity in both ...
Watson, Tom, White, Anna Marie
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

STRATEGI PENGHIMPUNAN DANA SOSIAL UMMAT PADA LEMBAGA-LEMBAGA FILLANTROFI DI INDONESIA (Studi Kasus Dompet Peduli Ummat Daarut Tauhid, Dompet Dhuafa Republika, BAZNAS, dan BAZIS DKI Jakarta)

Li Falah: Jurnal Studi Ekonomi dan Bisnis Islam, 2016
This study aimed to describe forms of fundrising conducted by institutions fillantrofi in Indonesia. The study was conducted at four institutions namely DPU Daarut Tauhid, Dompet Dhuafa Republika, BAZNAS, and BAZIS of DKI Jakarta.
N.Oneng Nurul Bariyah
doaj  

Investor Behavior in Hedged Mutual Funds: Evidence on Risk Chasing and Misallocation

Applied Finance Letters
Hedged mutual funds (HMFs), employing hedge-fund-like strategies such as leverage, short-selling, and derivatives, have become a significant segment of the U.S. fund industry.
Hasan Zafer Yuksel, Yinfei Chen, Steve Liu   +2 more
doaj   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Managing reputation for ‘good works’ while undertaking commercial activities - communications best practice guidelines for charities [PDF]

, 2010
Charities and not-for-profit organisations have traditionally eschewed commercial operations in favour of direct fund-raising from supporters. Competitive pressures, however, are driving charities to take on ‘dual citizenship’ (Goodall 2000) through ...
Watson, Tom, White, Anna Marie
core