Why does mutual fund performance not persist? The impact and interaction of fund flows and manager changes [PDF]
This paper investigates the reasons for the lack of long-term persistence in the investment performance of actively managed equity mutual funds. We document that the responses of investors, fund managers, and investment management companies to past ...
Bessler, Wolfgang +3 more
core
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Can Mutual Fund Managers Pick Stocks? Evidence from the Trades Prior to Earnings Announcements [PDF]
We test whether fund managers have stock-picking skill by comparing their holdings and trades prior to earnings announcements with the returns realized at those events.
Jessica A. Wachter +3 more
core
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Investment Strategies, Fund Performance and Portfolio Characteristics [PDF]
This paper studies the relation between fund performance and the fund manager's investment strategy, which is based on the characteristics of the portfolio.
Engström, Stefan
core
Flujos de inversión en fondos mutuos y comportamiento del inversionista: evidencia empírica en Chile
Estudios de Administración, 2010 This article is centered on those factors that are relevant forinvestors in equity Mutual Funds. More specifically it focuses on net flows that go to a fund and its relation with performance, costs and other variables.
Jorge Gregoire C., Herman Granzow C.
doaj +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Nonlinear effect of fund characteristics on mutual fund size under different fund manager's fee
, 2014 碩士本研究運用Gonza′lez,Teräsvirta and van Dijk（2004, 2005）發展的緃橫平滑移轉迴歸模型進行實證分析，探究資訊比率、基金淨值、基金週轉率等基金特性是否在不同基金經理人費用變化下對基金規模的影響性產生變化。本研究之基金經理人費用以基金費用率替代之。 根據實證結果顯示，當基金費用率小於0.0786(%)時，資訊比率與基金規模呈現顯著之正向關係；當基金費用率大於0.1636(%)時，資訊比率與基金規模呈現顯著之負向關係。無論基金費用率小於0.0786(%)、介於0 ...
陳景棋; Chen, Ching-Chi
core
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source