Results 141 to 150 of about 4,560,997 (208)
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
共同基?規模、績效與投資?為 Mutual Fund Size, Performance, and Investment Behavior
, 2013 [[abstract]]本研究討?基?規模、績效與經?人投資策?的關係。研究結果發現基?前期規模與當期績效呈 現負相關，顯示基?的績效表現隨著基?規模的成長而衰退。就基?規模與投資?為方面，我們 發現大規模的基?為因應資產的增加，會增加投資組合的持股?目與個股持股權重。最後，在基 ?規模與投資?為對基?績效的關係，結果發現基?持股家?的增加，有?於基?績效的表現。 然而，隨著基?規模成長到一定程?，可能囿於有限的?好投資標的，導致基?績效表現有衰退 的現象。 We examine the ...
?秋? Chiuling Lu, ?宗漢 Zong-Han Lin
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Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization
Molecular Oncology, EarlyView.In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu +13 more
wiley +1 more source
Other title: Supreme Court of Ohio : ... annual report, Lawyers' Fund for Client Protection
, 2015 Began with: 2015-; At head of cover title: Supreme Court of Ohio.; Covers the fiscal year: July 1-June 30.; Harvested from the web on 2/5/16The Fund provides financial reimbursement to law clients who have sustained losses resulting from the dishonest ...
Lawyers' Fund for Client Protection (Ohio). +1 more
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Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Children's Trust Fund [web site] [Harvested on 2014: Dec. 23]
, 2014 Updated irregularly; Began in 2002?; Title from home page (publisher's Web site, viewed May 17, 2011).; Official web site of the Children's Trust Fund of Connecticut, a division of the Dept. of Social Service.
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Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
An Evaluation of Mutual Fund Performance in an Emerging Economy: The Case of Pakistan
Lahore Journal of EconomicsThis article examines the performance of Pakistan’s mutual fund industry during 2006–10, a period characterized both by bullish and bearish markets.
Mahreen Mahmud, Nawazish Mirza
doaj
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source