Results 91 to 100 of about 1,680,581 (282)

MULTIDIMENSIONAL HYBRID BOUNDARY VALUE PROBLEM

open access: yesActa Polytechnica, 2018
The purpose of this paper is to discuss three types of boundary conditions for few families of special functions orthogonal on the fundamental region. Boundary value problems are considered on a simplex F in the real Euclidean space Rn of dimension n >
Marzena Szajewska   +1 more
doaj   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Matriz tridimensional para la aproximación al aseguramiento de la calidad en la educación a distancia

open access: yesEducare, 2015
El aseguramiento de la calidad en la Educación a Distancia constituye un factor fundamental del éxito de esta modalidad educativa. En este artículo se aborda el aseguramiento de la calidad siguiendo un enfoque matricial tridimensional.
Mauro José Hernandez Delgado   +2 more
doaj  

Hermenéutica y Argumentación: Aportes para la comprensión del diálogo intercultural

open access: yesEstudios de Filosofía, 2016
En las actuales sociedades pluralistas, el encuentro de racionalidades heterogéneas ha llevado al surgimiento de conflictos interculturales cuya solución suele esperarse de la instauración de espacios de diálogo intercultural.
Catalina Hidalgo Nieto
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

La Teología Fundamental como teología del encuentro entre la revelación y el hombre

open access: yesEstudios Eclesiásticos, 1986
Este estudio profundiza en el concepto de Teología Fundamental según Heinrich Fries, cuya obra se apoya sobre todo en el encuentro y la mediación entre la revelación y el hombre.
Antonio Jiménez Ortiz
doaj  

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard   +5 more
wiley   +1 more source

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