Results 101 to 110 of about 1,680,581 (282)

Manifolds of even dimension with amenable fundamental group

Commentarii Mathematici Helvetici, 1994
The main topic of the paper is to investigate the relation between the Euler characteristic and the fundamental group \(\pi\) of a closed 4-manifold \(X\). The paper deals with the question, when \(\chi(X)\geq 0\) resp. \(\chi(X)=0\) holds and when \(X\) is aspherical, i.e. all higher homotopy groups of \(X\) vanish. The main results are: 1. If \(\pi\)
openaire   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Metric dimension of star fan graph

Scientific Reports
Every node in a network is said to be resolved if it can be uniquely identified by a vector of distances to a specific set of nodes. The metric dimension is equivalent to the least possible cardinal number of a resolving set.
S. Prabhu, D. Sagaya Rani Jeba, Sudeep Stephen   +2 more
doaj   +1 more source

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

AMENAZA, VULNERABILIDAD Y SOCIEDADES URBANAS UNA VISIÓN DESDE LA DIMENSIÓN INSTITUCIONAL

Gestión y Ambiente, 2008
Hoy en día, el desarrollo, ojalá sostenible, de los hábitats urbanos no puede abstraerse de condiciones intrínsecas de amenazas de origen natural, puesto que la expansión territorial de las urbes, sobre todo en los países en vía de desarrollo, obliga a ...
ANNE CATHERINE CHARDON
doaj   +2 more sources

Lorentz violating backgrounds from quadratic, shift-symmetric, ultralight dark matter

Journal of High Energy Physics
We consider an effective theory for a shift-symmetric, quadratically-coupled, ultralight spin-0 field. The leading CP conserving interactions with Standard Model fields in the effective theory arise at dimension 8.
Minyuan Jiang, Benjamin D. Pecjak, Gilad Perez, Somasundaram Sankaranarayanan   +3 more
doaj   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Torrego, J. C. (Coord.) Gómez, M. J., Martínez, C. y Negro, A. (2014). La tutoría en los centros educativos. 8 ideas clave. (Barcelona, Graó). 224 pp.

Revista Española de Pedagogía, 2015
La tutoría aborda los procesos más personalizados de la educación desde una perspectiva educativa y constituye un recurso fundamental en un modelo educativo de calidad.
Isabel Cantón Mayo
doaj  

Methylation biomarkers can distinguish pleural mesothelioma from healthy pleura and other pleural pathologies

Molecular Oncology, EarlyView.
We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck, Nele De Meulenaere, Thomas Vanpoucke, Joe Ibrahim, Dieter Peeters, Suresh Krishan Yogeswaran, Wen Wen, Paul Van Schil, Jeroen M. H. Hendriks, Jo Raskin, Jan van Meerbeeck, Guy Van Camp, Ken Op de Beeck   +12 more
wiley   +1 more source