Results 71 to 80 of about 1,680,581 (282)
Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
An Analytical Method for Construction of a Fundamental Portfolio
Prace Naukowe Uniwersytetu Ekonomicznego we Wrocławiu, 2019 The classical models used for the construction of an investment portfolio do not take into account the fundamental values of the companies in question.
Paweł Kliber, Anna Rutkowska-Ziarko
doaj
Evaluating the Fractal Pattern of the Von Koch Island Using Richardson’s Method
Fractal and FractionalThe principles of fractal geometry have revolutionized the characterization of complex geometric objects since Benoit Mandelbrot’s groundbreaking work.
Maxence Bigerelle +2 more
doaj +1 more source
The newfound relationship between extrachromosomal DNAs and excised signal circles
FEBS Letters, EarlyView.Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley +1 more source
Studies in Applied Linguistics & TESOL, 2014 In this forum, we invited seven contributors to reflect upon the trend of LOA as portrayed in TCCRISLS 2014. Lauren Wyner overviews the nature of learning-oriented assessment from a historical perspective.
Heidi Han-Ting Liu
doaj +1 more source
Fundamental Units of Measurement and Extra Dimensions
Advances in High Energy Physics, 2022 The space available to our perception is three-dimensional with full evidence. The development of physics led to the hypothesis of extra dimensions. It is believed that an important role in the unification of physics should play by the Planck units of mass, length and time, built on the universal constants
openaire +2 more sources
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Culture and Identity: Two Emerging Topics in Hungarian Constitutional Law
Institutiones AdministrationisThe paper discusses the concepts of culture and identity within the context of the Fundamental Law of Hungary. The first part focuses on the relationship between the state and culture, both from a conceptual and an ideological point of view.
Miklós Könczöl
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Affectivité, sens et affects : les émotions comme articulation de la vie biologique
Acta Universitatis Carolinae: Philologica, 2018 This article argues that attempts by philosophy to think emotions as embodied is caught between the necessity of thinking them as a subjective first person dimension of experience on the one hand and as an objective biological determination on the other.
Ian James
doaj +1 more source