Results 81 to 90 of about 1,680,581 (282)

Fundamentals of Geometric Dimensioning and Tolerancing

, 2023
{"references": ["Geometric Dimensioning and Tolerancing, ASME Y14.5-2018, American Society of Mechanical Engineers, New York, NY, 2018.", "R. Bundynas, K. Nisbett, Shigley's Mechanical Engineering Design, 10th Ed., McGraw-Hill, 2014."]}
openaire   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Advances in Magnetic Nanomaterials and Nanostructures

Magnetochemistry
Magnetic nanomaterials, in which non-bulk magnetic properties emerge because of their low dimension, are a class of materials with huge application potential in several areas, providing, at the same time, an exciting field of fundamental research [...]
Francesco Congiu, Giorgio Concas
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Inherent Characteristics Study of Megawatt Wind Turbine Tower

Kongzhi Yu Xinxi Jishu, 2013
Mechanical model of a MW wind turbine tower was established and the fundamental frequency of bending vibration and torsional vibration was obtained by Rayleigh method in this paper. The influence of the diameter, thickness, taper angle, up structure mass,
WANG Yongsheng, ZHAO Ping, YAN Zhiwei, LV Xingmei, YI Quan   +4 more
doaj  

The Birth of Ethos out of Pathos

Critical Hermeneutics
An ethical epoché is required to leave the terrain of a self-evident morality and question its origin. In particular, four fundamental motifs of the ethical dimension are identified: pathos, to be thematised as an alternative to the persistent activist ...
Bernhard Waldenfels
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Experience and education in social field. Elements of analysis in a Freirian perspective

Encyclopaideia, 2017
The article deals with the link between social dimension and educational action. First of all, the text addresses the actual crisis of the social dimension in the conditions of everyday life.
Piergiorgio Reggio
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source