Results 221 to 230 of about 8,229,549 (389)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

The Fundamental Frequency of Voice as a Potential Stress Biomarker: A Systematic Review and Meta-Analysis. [PDF]

Stress Health
Veiga DL, Almeida TM, Uchida RR, Cordeiro Q.   +3 more
europepmc   +1 more source

Convergence in voice fundamental frequency during synchronous speech. [PDF]

PLoS One, 2021
Bradshaw AR, McGettigan C.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Neural Coding of Fundamental Frequency and Processing of Discrete Pitch Accents in Middle Age. [PDF]

Eur J Neurosci
McHaney JR, Guo ZC, Gnanateja GN, Parthasarathy A, Chandrasekaran B.   +4 more
europepmc   +1 more source

Spectral Aggregate of the High-Passed Fundamental Frequency and Its Relationship to the Primary Acoustic Features of Adductor Laryngeal Dystonia. [PDF]

J Speech Lang Hear Res, 2022
Marks KL, Feaster TF, Baker S, Díaz-Cádiz ME, Doyle PC, Stepp CE.   +5 more
europepmc   +1 more source

An AlGaAs/GaAs‐based planar Gunn diode oscillator with a fundamental frequency operation of 120 GHz [PDF]

, 2014
Mohamed Ismaeel Maricar, J. Glover, Ata Khalid, Chong Li, G. A. Evans, David R. S. Cumming, Christopher H. Oxley   +6 more
openalex   +1 more source

Optimization of graphene/fibre reinforced cantilever skew laminates for maximum fundamental frequency via non-uniform distribution of reinforcements

, 2023
Y. Jeawon, Georgios Α. Drosopoulos, G. Foutsitzi, Georgios Ε. Stavroulakis, Sarp Adali   +4 more
openalex   +1 more source

Methods for the speech fundamental frequency estimation

, 2008
This paper deals with the fundamental frequency of the speech signal. Five methods for the fundamental frequency estimation were described and analyzed: autocorrelation, central clipping, inverse filter, spectral and cepstral method.
Atassi, Hicham
core  

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source