Results 141 to 150 of about 6,143,449 (300)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Direct Parent Engagement to Improve Fundamental Movement Skills in Children: A Systematic Review

Fundamental movement skills (FMS) are basic movements in children that represent the building blocks for more complex motor skill development, and act as a prerequisite for enduring sport and physical activity (PA) engagement and positive health-related ...
Roscoe, C., Pringle, A., Flynn, R.
core  

A Decade of Fundamental Movement Skills in Elementary Schools: A Bibliometric Study Scopus Database 2014-2023

E-Jurnal Physical Education, Sport, Health and Recreation
Fundamental movement skills are very important and have an impact on children’s development. This research aims to explore and analyze articles related to fundamental movement skills in elementary schools over the last decade through a bibliometric study
Sulthan Hadist Ismaiedh Cukarso, Sujarwo, Yasep Setiakarnawijaya, O. U. Subandi   +3 more
semanticscholar   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Preschool and parental influences on physical activity and fundamental movement skills in preschool children from low socio-economic backgrounds: A qualitative study. [PDF]

, 2016
PA levels of children attending different preschools have been reported as varying greatly, with the characteristics of the preschool influencing a child’s PA level (Pate, Pfeiffer, Trost, Ziegler and Dowda, [2004], Pediatrics 114, 1258-1263).
Birch, Samantha, James, Rob S., Roscoe, Clare M. P., Duncan, Michael J.   +3 more
core  

Advancing movement and physical literacy earlier (AMPLE) program for promoting physical literacy and executive function among young children: study protocol of a cluster randomized crossover trial

BMC Public Health
Background The positive impact of fundamental movement skills on physical activity in young children has been shown in previous studies, but little is known about the association between fundamental movement skills and cognitive development in young ...
Zheng Ye, James Robert Rudd, Jia Yi Chow, Cindy Hui Ping Sit, Suzannie Kit Ying Leung, Siu Ming Choi , Minghui Li, Raymond Kim Wai Sum   +7 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Skills in Higher Education

, 2011
This unit contains a PowerPoint presentation about assessing key skills, with explanatory notes, and an audio recording of the two authors talking through the presentation.
Dr Rosalind Duhs, Dr. Rosalind Duhs, Dr. Jenny Marie, Dr Jenny Marie   +3 more
core  

Application of Traditional Games to the Fundamental Movement Skills of Children 5-6 Years of Age

International Journal of Disabilities Sports & Health Sciences
This research is motivated by children's fundamental movement skills, which are less than optimal. Mastery of fundamental movement skills that are less than optimal will affect the achievement of further movement skills.
Aprilia Wahyuning Fitri, D. Dimyati, Y. Ayriza   +2 more
semanticscholar   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source