A general model for analysis of linear and hyperbolic enzyme inhibition mechanisms
FEBS Open Bio, EarlyView.We developed a general enzyme kinetic model that integrates these six basic inhibition mechanism onto a single one. From this model, we deduced a general enzyme kinetic equation that through modulation of simple parameters, γ (the relative inhibitor affinity for two binding sites) and β (the reactivity of the enzyme–substrate–inhibitor complex), is ...
Rafael S. Chagas, Sandro R. Marana
wiley +1 more source
Compact groups of galaxies (CGs) from the SDSS Data Release 6
Open Physics, 2008 Deng Xin-Fa +4 more
doaj +1 more source
Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays
FEBS Open Bio, EarlyView.We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul +3 more
wiley +1 more source
Determining fundamental transport parameters of hydrogen isotopes in tungsten [PDF]
, 2017 G. Holzner +2 more
openalex
Fundamental parameters of 49 new star clusters in GAIA DR2
, 2021 Zhongmu Li, Yangyang Deng, Jing Chen
openalex +2 more sources
Overview of molecular signatures of senescence and associated resources: pros and cons
FEBS Open Bio, EarlyView.Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas +6 more
wiley +1 more source
Fundamental parameters of four massive eclipsing binaries in Westerlund 1 [PDF]
, 2012 E. Koumpia, A. Z. Bonanos
openalex +1 more source
Fundamental parameters for dEB SB2 binary system J064726.39+223431.6 [PDF]
, 2022 Михаил Михайлович Ковалев +3 more
openalex +1 more source
Clusters as benchmarks for measuring fundamental stellar parameters
, 2016 In this contribution I will discuss fundamental stellar parameters as determined from young star clusters; specifically those with ages less than or approximately equal to that of the Pleiades. I will focus primarily on the use of stellar evolutionary models to determine the ages and masses of stars, as well as discussing the limitations of such models
openaire +2 more sources
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source