Results 61 to 70 of about 290,567 (259)

Germline TP53 Mutations Causing Diamond–Blackfan Anemia: A French Report

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Diamond–Blackfan anemia is a rare congenital erythroblastopenia typically caused by mutations in ribosomal protein genes. Recently, gain‐of‐function mutations in TP53 have been identified as a novel cause of Diamond–Blackfan anemia. We report two French patients who both harbored a heterozygous TP53 deletion (NM_000546.5: c.1077delA; p ...
Rafael Moisan, Lydie Da Costa, Ludivine David Nguyen, Heloise Chosseler, Audrey Riquet, Benedicte Bruno, Melissa Barbati   +6 more
wiley   +1 more source

Health‐Related Quality of Life and Symptom Severity Among Patients With PIK3CA‐Related Overgrowth Spectrum: A Mixed‐Methods Study to Understand Real‐World Experience With Alpelisib Treatment

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background PIK3CA‐related overgrowth spectrum (PROS) includes several rare overgrowth disorders resulting from somatic gain‐of‐function mutations in PIK3CA. Despite treatment advances, including the recent approval of alpelisib for PROS in the United States, literature detailing the patient experience with PROS is limited.
Vamsi Bollu, Kaitlin LaGasse, Cory D. Saucier, Kimberly Raymond, Miranda Lauher‐Charest, Lauren Crowder, Beilei Cai, Mary Lisha Paul, Denise Adams   +8 more
wiley   +1 more source

‘They Need to Hear You Say It’: Healthcare Professionals’ Perspectives on Barriers and Enablers to End‐of‐Life Discussions With Adolescents and Young Adults With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT End‐of‐life conversations with adolescents and young adults (AYAs) with cancer rarely occur without the guidance of healthcare professionals. As a part of the ‘Difficult Discussions’ study, focused on palliative care and advance care planning discussions with AYAs with cancer, we investigated the factors that healthcare professionals identify ...
Justine Lee, Holly Evans, Claire E. Wakefield, Antoinette Anazodo, Richard J. Cohn, Brittany C. McGill, Elizabeth A. Lobb, Lori Wiener, Madeleine L. Juhrmann, Ursula M. Sansom‐Daly   +9 more
wiley   +1 more source

Revisiting the Fundamental Metallicity Relation with Observation and Simulation

The Astrophysical Journal Letters
The gas-phase metallicity of galaxies is regulated by multiple astrophysical processes, which makes it a crucial diagnostic of galaxy formation and evolution.
Chengyu Ma, Kai Wang, Enci Wang, Yingjie Peng, Haochen Jiang, Haoran Yu, Cheng Jia, Zeyu Chen, Haixin Li, Xu Kong   +9 more
doaj   +1 more source

Fundamental hoop-algebras

Ratio Mathematica, 2015
In this paper, we investigate some results on hoop algebras and hyper hoop-algebras. We construct a hoop and a hyper hoop on any countable set. Then using the notion of the fundamental relation we define the fundamental hoop and we show that any hoop is ...
R.A. Borzooei, H.R. Varasteh, K. Borna
doaj   +1 more source

Feasibility and Safety of High‐Dose Proton Re‐Irradiation in Recurrent Pediatric Central Nervous System Tumors: A Single‐Institution Retrospective Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Purpose Pediatric central nervous system (CNS) tumors often recur despite multimodality therapy. Although re‐irradiation (re‐RT) has historically been limited by concerns for severe late toxicities, modern techniques have renewed interest in this approach. Proton therapy provides dosimetric advantages that may enable curative re‐treatment with
Jin‐Ho Song, Jonathan Baron, Carlos Chavez Perez, Sidharth Ramesh, Jane Minturn, Kavita A. Desai, Amish C. Shah, Jean M. Belasco, Kristina A. Cole, Michael J. Fisher, Phillip B. Storm, Peter M. Madsen, Goldie Kurtz, Robert A. Lustig, Christine Hill‐Kayser, Michael J. LaRiviere   +15 more
wiley   +1 more source

Teaching relational database fundamentals [PDF]

Proceedings of the 3rd Conference on Computing Education Practice, 2019
This paper describes and evaluates changes introduced in six successive\ud years teaching a relational databases module. We explain\ud how we plan to obtain some certainty on the value of interventions.\ud Using an archive of data over the period, we find some interventions\ud that should not be repeated.
openaire   +1 more source

Transitivity of the εm-relation on (m-idempotent) hyperrings

Open Mathematics, 2018
On a general hyperring, there is a fundamental relation, denoted γ*, such that the quotient set is a classical ring. In a previous paper, the authors defined the relation εm on general hyperrings, proving that its transitive closure εm∗$\begin{array}{} \
Norouzi Morteza, Cristea Irina
doaj   +1 more source

Defining Roles in Pediatric Palliative Care: Perspectives From Oncology and Palliative Care Teams

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Early integration of pediatric palliative care (PPC) is associated with improved symptom management, quality of life, and healthcare utilization for children with cancer. Despite this, variation persists in how PPC is understood, operationalized, and integrated within pediatric oncology programs. In particular, ambiguity surrounding
Leeat Granek, Lori Wiener, Stephanie Veldhuijzen van Zanten, Donna Johnston, Fyeza Hasan, Adam Rapoport, Nathasha Datoo, Kimberley Widger, Sumit Gupta, Karen Fergus, Anthony K. C. Chan, Alisha Kassam, Emily McCullogh, Dave Lysecki   +13 more
wiley   +1 more source

The Fundamental k-Form and Global Relations

Symmetry, Integrability and Geometry: Methods and Applications, 2008
In [Proc. Roy. Soc. London Ser. A 453 (1997), no. 1962, 1411-1443] A.S. Fokas introduced a novel method for solving a large class of boundary value problems associated with evolution equations.
Anthony C.L. Ashton
doaj