Results 111 to 120 of about 3,545,390 (309)

Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions

open access: yesFEBS Letters, EarlyView.
This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten   +10 more
wiley   +1 more source

A representação do conhecimento e o conhecimento da representação: algumas questões epistemológicas

open access: yesCiência da Informação, 1993
A organização e representação do conhecimento são de fundamental interesse para a recuperação e disseminação da informação. Consideramos oportuno indagar acerca das premissas epistemológicas Implícitas na representação do conhecimento e o conhecimento da
Maria Nélida González de Gomez
doaj  

Ablation of LRP6 in alpha‐smooth muscle actin‐expressing cells abrogates lung inflammation and fibrosis upon bleomycin‐induced lung injury

open access: yesFEBS Letters, EarlyView.
Low‐density lipoprotein receptor‐related protein 6 (LRP6) is a key receptor for the Wnt antagonist Dickkopf1 (DKK1). DKK1 protein expression is induced in a bleomycin (BLM)‐induced lung injury model. We show that DKK1 induces proinflammatory and profibrotic genes in lung fibroblasts.
Eun‐Ah Sung   +6 more
wiley   +1 more source

Structure of polynomial representations for orthosymplectic Lie superalgebras [PDF]

open access: yesarXiv, 2010
Orthosymplectic Lie superalgebras are fundamental symmetries in modern physics, such as massive supergravity. However, their representations are far from being thoroughly understood. In the present paper, we completely determine the structure of their various supersymmetric polynomial representations obtained by swapping bosonic multiplication ...
arxiv  

Characteristics of the Kelch domain containing (KLHDC) subfamily and relationships with diseases

open access: yesFEBS Letters, EarlyView.
The Kelch protein superfamily includes 63 members, with the KLHDC subfamily having 10 proteins. While their functions are not fully understood, recent advances in KLHDC2's structure and role in protein degradation have highlighted its potential for drug development, especially in PROTAC therapies.
Courtney Pilcher   +6 more
wiley   +1 more source

Symmetric Wilson Loops beyond leading order

open access: yesSciPost Physics, 2016
We study the circular Wilson loop in the symmetric representation of U(N) in $\mathcal{N} = 4$ super-Yang-Mills (SYM). In the large N limit, we computed the exponentially-suppressed corrections for strong coupling, which suggests non-perturbative ...
Xinyi Chen-Lin
doaj   +1 more source

Quantum Borcherds-Bozec algebras and their integrable representations [PDF]

open access: yesarXiv, 2019
We investigate the fundamental properties of quantum Borcherds-Bozec algebras and their representations. Among others, we prove that the quantum Borcherds-Bozec algebras have a triangular decomposition and the category of integrable representations is semi-simple.
arxiv  

The apo LETM1 F‐EF‐hand adopts a closed conformation that underlies a multi‐modal sensory role in mitochondria

open access: yesFEBS Letters, EarlyView.
We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin   +2 more
wiley   +1 more source

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

open access: yesFEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra   +7 more
wiley   +1 more source

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