Results 111 to 120 of about 129,190 (318)
Molecular Oncology, EarlyView.The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Trastuzumab‐deruxtecan, a HER2‐targeting antibody‐drug conjugate, shows promising antitumor activity in head and neck squamous cell carcinoma with low HER2 expression. In vitro and in vivo studies demonstrated dose‐dependent cell death and tumor growth reduction in low HER2‐expressing cell lines, which correlated with drug accumulation measured using a
Abdullah Bin Naveed +8 more
wiley +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
PROTAGONISMO JUDICIAL NO BRASIL: em busca da concretização de direitos fundamentais sociais
Revista de Políticas Públicas, 2014 This text makes an analysis about the each time more determinant acting of the Brazilian Judiciary to turn effective the fundamental social rights, attempting to comprehend this phenomenon, its causes and consequences.
Ana Teresa Silva de Freitas
doaj
Homelessness And The Issue of Freedom [PDF]
Journal of Constitutional Law, 2019 In this article the author explores the relationship between homelessness, the rules of public and private property, and the underlying freedom of those who are condemned by poverty to walk the streets and sleep in the open.
Jeremy Waldron
doaj
From Human Rights to Fundamental Rights - Consequences of a Conceptual Distinction [PDF]
, 2006 Gianluigi Palombella
openalex +1 more source
Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma
Molecular Oncology, EarlyView.The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias +12 more
wiley +1 more source
Revista Interdisciplinar de Direito, 2009 The central motivation of this article aims to identify the determinants of Ineff ec-tiveness of social rights and propose a solution to this problem consistent with the new constitutionalism based on the legalization of ...
Alfredo Canellas Guilherme da Silva
doaj
Transformation or Dilution: Fundamental Rights in the EU Social Space [PDF]
, 2006 Sandra Fredman
openalex +1 more source