Results 141 to 150 of about 5,275,514 (388)
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source
Molecular Oncology, EarlyView.This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan +9 more
wiley +1 more source
State duties of protection and fundamental rights [PDF]
Potchefstroom Electronic Law Journal, 2000 Duties of protection are duties of the state to protect certain legal interests of its citizens. They cover the interests of life, health, freedom and property and also protect some other interests and certain constitutionally recognised institutions ...
C Starck
doaj
Respect of the Article 8 of the European Convention for the Protection of Human Rights and Fundamental Freedoms in the recent case law of the European Court of Human Rights [PDF]
, 2020 Vojvodić Jovana D.
openalex +1 more source
INTERNATIONAL ECONOMIC LAW: IS THERE ANY TENSION BETWEEN THE TRADE REGIME AND HUMAN RIGHTS? [PDF]
It is well-known that being efficiency-oriented and utilitarian, the International Economic Law focuses on the market itself, while the human rights should protect the individual within the global economy. During the first part of the XXth century, human
Tăbușcă Silvia
core
Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology
Molecular Oncology, EarlyView.Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts +8 more
wiley +1 more source
PROTAGONISMO JUDICIAL NO BRASIL: em busca da concretização de direitos fundamentais sociais
Revista de Políticas Públicas, 2014 This text makes an analysis about the each time more determinant acting of the Brazilian Judiciary to turn effective the fundamental social rights, attempting to comprehend this phenomenon, its causes and consequences.
Ana Teresa Silva de Freitas
doaj
A new challenge: the fundamental social rights [PDF]
Democrazia e Diritti Sociali, 2018 Due to the current economic public condition, fundamental social rights are today condemned to be marginalized under the false accusation of implying unrealistic costs.
Luigi Di Santo
doaj