Results 151 to 160 of about 269,891 (340)

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

open access: yesMolecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen   +17 more
wiley   +1 more source

A note on the exact sequence of Hodge theoretic fundamental groups [PDF]

open access: yesarXiv
The goal of this short note is to study a right exact sequence of Hodge theoretic fundamental groups associated to a smooth projective family of algebraic varieties $f:X\to B$ first proven in \cite{Xu24}. In particular, we study when this right exact sequence is exact, relate this question to some beautiful results in non-abelian Hodge theory, and give
arxiv  

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

open access: yesMolecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane   +16 more
wiley   +1 more source

The Illusion of Rights based AI Regulation [PDF]

open access: yesarXiv
Whether and how to regulate AI is one of the defining questions of our times - a question that is being debated locally, nationally, and internationally. We argue that much of this debate is proceeding on a false premise. Specifically, our article challenges the prevailing academic consensus that the European Union's AI regulatory framework is ...
arxiv  

The Hierarchy of Fundamental Rights

open access: yes, 2019
The article is devoted to the study of the hierarchy of fundamental human rights in Ukraine and Germany. Following a comparative analysis of Ukrainian and German doctrines on fundamental human rights, the nature of the hierarchy of fundamental human rights is investigated and the conditions under which this hierarchy of human rights is possible is ...
openaire   +2 more sources

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas   +15 more
wiley   +1 more source

Clinical forensic imaging and fundamental rights in Austria. [PDF]

open access: yesForensic Sci Res, 2017
Kerbacher S   +3 more
europepmc   +1 more source

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