Results 81 to 90 of about 129,190 (318)
FEBS Letters, EarlyView.Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
Homoafetive Union: A Question of Fundamental Rights
Revista Brasileira de Direitos e Garantias Fundamentais, 2016 It analyzes the right to same-sex marriage. It presents different views on subjects related to the subject, to identity and to gender. It addresses fundamental rights and the constitutional principles applicable to the topic.
Renata Caroline Pereira Reis Mendes +1 more
doaj +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
The fundamental rights challenges of algorithms [PDF]
Netherlands Quarterly of Human Rights, 2019 Algorithms form an increasingly important part of our daily lives, even if we are often unaware of it. They are enormously useful in many different ways. They facilitate the sharing economy, help detect diseases, assist government agencies in crime control, and help us choose what series or film to watch. Yet, there is also a darker side to algorithms,
openaire +4 more sources
Mapping the evolution of mitochondrial complex I through structural variation
FEBS Letters, EarlyView.Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin +2 more
wiley +1 more source
Human Rights and Fishing: A Multidimensional Challenge
Baltic Journal of Law & Politics, 2019 In the last few years, it has been recognized more and more that human rights also play a role in the maritime sector. Human rights violations at sea are easy to overlook because they happen largely out of sight of most of society and they are based ...
Kirchner Stefan
doaj +1 more source
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
Fundamental Rights: Discursive Thinking Through of Unconcealed [PDF]
Философия и космологияThis article contributes to the discussion on the nature of rights, law, and justice. Rights are defined by the Greco-Latin concept of thémis/fas, while law and justice are characterized by díke/ius, with both being explored through physics, ethics, and ...
Oleg Bazaluk
doaj +1 more source
Multisystemic resilience to shocks: a temporal analysis of health, fundamental rights and freedoms, and economic resilience during the first wave of the COVID-19 pandemic in 22 European countries. [PDF]
BMJ Open, 2023 Clausin M +6 more
europepmc +1 more source
FEBS Letters, EarlyView.Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia +5 more
wiley +1 more source