Results 121 to 130 of about 5,509,064 (298)
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
The Method of Fundamental Solutions for Inverse and Moving Rigid Body Problems
, 2007 在本論文中，採用基本解法來分析反算及移動剛體之問題。在開始時，將基本解法結合矩陣的條件數來分析反算問題，包含二維拉普拉司方程式、柯西問題、遺失邊界條件和內部資料問題、散佈資料問題以及外型反算識別問題。再者，將基本解法結合穩態的史托克斯例來求解過度指定和不足指定部分邊界的反算史托克斯問題。史托克斯例的係數可以從任意兩個場域變數，例如速度、壓力、渦度或是流線函數來求得。將數值解和解析解加以比較均可以得到良好的結果。 接著，將基本解法與非穩態史托克斯例加以合併，加上對反算問題的數值經驗 ...
陳哲維, Chen, Chi-Wei
core
Preconditioners and fundamental solutions
, 2003 New preconditioning techniques for the iterative solution of systems of equations arising from discretizations of partial differential equations are considered.
Sundqvist, Per
core +2 more sources
Fundamental Solutions of the Equations of Classical and Generalized Heat Conduction Models
Учёные записки Казанского университета: Серия Физико-математические наукиThis article presents the mathematical formulations of transient heat conduction problems corresponding to the models of classical heat conduction using the Fourier law and generalized heat conduction based on the Cattaneo–Vernotta–Lykov law (Maxwell ...
A. A. Orekhov +2 more
doaj +1 more source
Fundamental Solutions and Gegenbauer Expansions of Helmholtz Operators in Riemannian Spaces of Constant Curvature. [PDF]
Symmetry Integrability Geom Methods Appl, 2018 Cohl HS, Dang TH, Dunster TM.
europepmc +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Fundamental solutions and dual boundary element methods for fracture in plane Cosserat elasticity. [PDF]
Proc Math Phys Eng Sci, 2015 Atroshchenko E, Bordas SP, Bordas SP.
europepmc +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source