Results 111 to 120 of about 31,990 (181)
Smart Molecules, EarlyView.This review elucidates the photophysical mechanisms of cellulose‐based room temperature phosphorescent materials and systematically outlines their construction strategies, such as cluster emission center engineering. This article demonstrates their applications in fields like information encryption and bioimaging, and looks ahead to the core challenges
Shasha Wu +10 more
wiley +1 more source
World Journal of Otorhinolaryngology - Head and Neck Surgery, EarlyView.ABSTRACT Obstructive sleep apnea is a clinical syndrome that triggers a series of pathophysiologic changes, including disturbed sleep architecture, chronic intermittent hypoxia and hypercapnia, and ultimately severe cognitive dysfunction. The hippocampus plays a key role in various cognitive processes such as learning and memory.
Rui Fan, Tao Li, Yan Yan
wiley +1 more source
Micro‐Mechanism Informed Neural Networks for Process‐Property Prediction in Laser Powder Bed Fusion
Artificial Intelligence for Engineering, EarlyView.Hard physics embedding, where neural networks learn residuals relative to analytical baselines, substantially outperforms soft loss‐function constraints for extrapolation in LPBF process–property prediction. Physics integration architecture determines generalization capability more than constraint quantity.
Yo‐Lun Yang
wiley +1 more source
CAAI Transactions on Intelligence Technology, EarlyView.ABSTRACT This paper proposes a boundary control method for nonlinear distributed parameter systems (DPSs) with limited boundary measurements (BMs), as typically encountered in networked cyber‐physical processes with spatially distributed dynamics such as thermal and biomedical diffusion systems.
Yanlin Li +5 more
wiley +1 more source
Beyond the next step: A multi‐criteria generative validation framework for step selection functions
Methods in Ecology and Evolution, EarlyView.Abstract Step‐selection functions (SSFs), typically fitted using step‐selection analysis (SSA) or integrated step‐selection analysis (iSSA) are widely used to infer habitat selection and movement kernels from high‐frequency telemetry data, but most standard validation tools focus on one‐step‐ahead prediction and do not guarantee that fitted models ...
Aurélien Nicosia
wiley +1 more source
Methods in Ecology and Evolution, EarlyView.Abstract Step‐selection analysis (SSA) is a popular tool for estimating resource/habitat selection conditional on the local availability of conditions as determined by an animal's movement capacity. These models can be subsequently used to parameterize a movement model; however, most SSAs focus instead merely on interpreting the direction and magnitude
Natasha Ellison‐Neary +4 more
wiley +1 more source
Allergy, EarlyView.ABSTRACT In the last decades, critical advancements in research technology and knowledge on disease mechanisms steered therapeutic approaches for chronic inflammatory diseases towards unprecedented target specificity. For allergic and chronic lung diseases, biologic drugs pioneered this goal, acquiring on the way—through the clinical use of monoclonal ...
F. Roth‐Walter +20 more
wiley +1 more source
Compartmentalisation in cAMP signalling: A phase separation perspective
British Journal of Pharmacology, EarlyView.Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley +1 more source
Non‐canonical PKG1 regulation in cardiovascular health and disease
British Journal of Pharmacology, EarlyView.It is well established that the cyclic GMP‐dependent protein kinase I (PKG1) is canonically activated by cyclic guanosine monophosphate (cGMP), enabling its regulation of vascular tone, cardiac function and smooth muscle homeostasis. However, diverse non‐canonical stimuli of PKG1 have also been identified.
Jie Su, Joseph Robert Burgoyne
wiley +1 more source
New biosensors and transgenic mice for multiplex cGMP imaging
British Journal of Pharmacology, EarlyView.Background and Purpose Cyclic guanosine monophosphate (cGMP) is a versatile second messenger that is important for human (patho‐)physiology and pharmacotherapy. Live‐cell imaging of cGMP with biosensors allows to elucidate its spatiotemporal dynamics in real time under close‐to‐native conditions. However, to monitor two separate cGMP pools or cGMP/cAMP
Markus Wolters +6 more
wiley +1 more source