Results 151 to 160 of about 61,867 (215)

De Novo Design of Membrane‐Targeting Antimicrobial Peptides Against Gram‐Negative Bacteria Using a Generative Artificial Intelligence Framework

Advanced Science, EarlyView.
Antimicrobial resistance caused by Gram‐negative bacteria remains difficult to overcome due to the protective outer membrane. To address this challenge, a multi‐condition constrained generative AI framework, GenMTAMP is proposed for de novo membrane‐targeting antimicrobial peptide design by integrating physicochemical and spatial structure descriptors.
Jingxiao Yu, Da‐Wen Sun, QingYi Wei, Yibing Zhang, Jidong Tang, Hongbin Pu   +5 more
wiley   +1 more source

Determinants of Productivity and Sustainability in Small-Scale Dairy Industries: Evidence From the Salale Zone of Oromia, Ethiopia. [PDF]

Vet Med Sci
Geleta GM.
europepmc   +1 more source

Closed‐Loop Radiative Cooling Mulch Upcycled From Agricultural Residues for Efficient Soil Heat–Water Stress Mitigation

Advanced Science, EarlyView.
Conventional passive radiative cooling films rely on costly feedstocks and energy‐intensive fabrication, with poor end‐of‐life compatibility in agriculture. To address this challenge, a sustainable radiative cooling mulch (SRCM) is developed from waste maize leaves via spontaneous hydrogen‐bond self‐assembly.
Hao Li, Dong Lv, Yang Fu, Cancheng Jiang, Wenqi Wang, Ze Li, Lin Liang, Jiayu Du, Jie Tan, Yihao Zhu, Wenjie Liu, Lamfeddal Kouisni, Kaixin Lin, Chi Yan Tso   +13 more
wiley   +1 more source

CCL3 and IL‐7 Synergistically Enhance CAR‐T Efficacy in Solid Tumors

Advanced Science, EarlyView.
Synergistic delivery of CCL3 and IL‐7 by CAR‐T cells overcomes the immunosuppressive tumor microenvironment by enhancing cell infiltration, survival, and local immune reprogramming. This also establishes positive feedback that amplifies anti‐tumor activity and memory responses in both CAR‐T and endogenous T cells, presenting a robust therapeutic ...
Huanpeng Chen, Xiaoyun Luo, Huixin Gao, Yujing Ke, Yu Zhan, Xiaoting Xu, Xiaoxiao Xiong, Fengjiao Wei, Si Yang, Zhonghua Liu, Bolan Yu, Zhaofeng Huang, Yingjie Bian   +12 more
wiley   +1 more source

Efficiency and economic performance of honey producers in southwest Nigeria: a comprehensive empirical analysis. [PDF]

Sci Rep
Ijigbade JO, Toluwase SOW, Agbede TM, Adetarami O, Ilemobayo OO, Imoru A.   +5 more
europepmc   +1 more source

Robust Amorphous MOF‐Based Aerogels Digital Biosensor for Sensitive Detection of Organophosphate Pesticides

Advanced Science, EarlyView.
We report a robust aerogel digital biosensor by integrating an enzyme‐mediated amorphous MOF within an aerogel matrix for on‐site pesticide detection. The enzyme‐mediated assembly strategy enables in situ tailoring of MOF into a porous amorphous structure, achieving both high stability and activity.
Changshun Su, Xiangyu Zhai, Houru Li, Yijie Wang, Hongxia Li, Yueyao Jiang, Geyu Lu, Xu Yan   +7 more
wiley   +1 more source

The impact of agricultural green development on common prosperity for farmers in rural areas. [PDF]

Sci Rep
Li Z, Shi Q, Hu K, Chen Z.
europepmc   +1 more source

A Brain‐Penetrant Nanobody Reveals GSK3β‐Driven Proline‐Directed Phosphorylation as a Master Regulator of Ischemic Neurodegeneration

Advanced Science, EarlyView.
A brain‐targeted nanoparticle enables delivery of a therapeutic nanobody (Nb.29E9) that inhibits pathogenic GSK3β signaling. This intervention restores AMPK/mTORC1/TGFβ homeostasis, attenuates neuroinflammation and oxidative stress, and promotes long‐term functional recovery after ischemic stroke.
Lan Li, Muyang Li, Lei Sun, Ying Yang, Yuanshun Wu, Ziyi Yin, Anni Wang, Peiyang Zhou, Shaoxiang Luo, Jian Chen, Jun Qin, Zhibing Ai, Zilong Yuan, Zhiqiang Dong, Min Zhang   +14 more
wiley   +1 more source

Hi-C guided genome assembly and karyotype analysis of the Indian population of Maruca vitrata (Lepidoptera: Crambidae) set the stage for structural and functional genomic insights. [PDF]

BMC Genom Data
Mohan M, Aneesha PJ, Ashok K, Gandhi Gracy R, Venkatesan T, Doddchowdappa S, Subaharan K, Jambagi SR, Anilkumar B, Vijayakumari N, Chandana CR, Sushil SN, Srinivasan R.   +12 more
europepmc   +1 more source

Synergistic HMGN1 and VP64 Fusions Potentiate High‐Precision and PAM‐Flexible Base Editing

Advanced Science, EarlyView.
A novel CDA1Δ‐SpRY architecture fused with HMGN1 and VP64 yields a nearly PAM‐less base editing platform. By focusing cytosine conversion predominantly at position −18, this synergistic complex ensures highly precise targeting. Demonstrating enhanced efficiency across diverse models, including yeast and rice, the platform offers a robust solution for ...
Xi Luo, Yuyao Qu, Zhengyan Ye, Zheng Li, Yuanyan Zhang, Longjiong Luo, Shaokang Li, Wei Zhao, Ming Wang, Ralph Bock, Jianmin Wan, Junjie Tan   +11 more
wiley   +1 more source