Results 51 to 60 of about 1,021,781 (312)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Screening of certain Ayurvedic plants extracts against E. turcicum [PDF]

, 2011
The use of chemicals against pathogens is environmentally dangerous, so use of natural inhibitors for disease management is needed. In this work we screen botanical extracts from ayurvedic plants for their antifungal properties against economically ...
Kaushal Kumar Bhati, R. Prasad, Rajesh Singh   +2 more
core   +1 more source

Fungal Transcriptomics

, 2018
Transcriptomics, the study of RNA molecules, provides in-depth understanding of cellular functions and the genomic landscape of transcription. Transcriptomics refers to the study of all classes on RNA molecules including mRNA, tRNA, and siRNA. In this chapter, we specifically focus on mRNA, which encodes the protein-coding portion of the genomic DNA ...
Singan, Vasanth R, Kuo, Rita C, Chen, Cindy   +2 more
openaire   +4 more sources

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Occupational Histoplasmosis: Epidemiology and Prevention Measures

Journal of Fungi, 2021
In areas where Histoplasma is endemic in the environment, occupations involving activities exposing workers to soil that contains bird or bat droppings may pose a risk for histoplasmosis. Occupational exposures are frequently implicated in histoplasmosis
Marie A. de Perio, Kaitlin Benedict, Samantha L. Williams, Christine Niemeier-Walsh, Brett J. Green, Christopher Coffey, Michelangelo Di Giuseppe, Mitsuru Toda, Ju-Hyeong Park, Rachel L. Bailey, Randall J. Nett   +10 more
doaj   +1 more source

CAR T‐Cell Therapy in Neurology: A Scoping Review of Neuro‐Oncology, Autoimmune Diseases & Neurotoxicity

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Chimeric antigen receptor (CAR) T‐cell therapy has been investigated in neurological diseases, encompassing both central nervous system malignancies and autoimmune disorders, thereby extending its application beyond hematological cancers.
Omar Alqaisi, Mohammed Dibas, Patricia Tai, Ala Dibas, Osama Souied, Suhair Al‐Ghabeesh   +5 more
wiley   +1 more source

Discovery of novel plant biomass conversion associated fungal transcription factors using a network-based approach

Current Research in Biotechnology
Fungal plant biomass conversion (FPBC) is an important component of the global carbon cycle and has been widely applied for the production of biofuels, enzymes and biochemicals.
Mao Peng, Astrid Mueller, Joanna E. Kowalczyk, Roland S. Kun, Ronald P. de Vries   +4 more
doaj   +1 more source

Phylogenetic congruence between subtropical trees and their associated fungi. [PDF]

, 2016
Recent studies have detected phylogenetic signals in pathogen-host networks for both soil-borne and leaf-infecting fungi, suggesting that pathogenic fungi may track or coevolve with their preferred hosts.
Etienne, Rampal S, Gilbert, Gregory S, Liang, Minxia, Liu, Xubing, Yu, Shixiao   +4 more
core   +3 more sources

Fungal and fungal-like plant pathogens of the Maltese Islands [PDF]

, 2006
The paper provides updated lists of plant pathogenic species belonging to the kingdoms Protozoa, Chromista and Fungi (one, 21, and 211 species entries, respectively) recorded in Malta.
Mifsud, David, Porta-Puglia, Angelo
core