Results 101 to 110 of about 6,148 (254)

Indirect effects of beneficial fungal treatments on pest insects can vary with plant genotype and spore viability

Biological Control
Fungal entomopathogens as biopesticides are typically applied as foliar sprays and assessed for their insecticidal activity. However, plant responses to these microbial treatments remain poorly understood.
Cesar U. Valencia, Janaina C.S. Cunha, Loren Rivera-Vega, Gregory A. Sword   +3 more
doaj   +1 more source

Effects of Live and Heat‐Treated Bifidobacterium longum CECT 7347 in Adults With Allergic Rhinitis: A Randomised, Double‐Blind, Placebo‐Controlled Trial

Allergy, EarlyView.
This randomized, double‐blind, placebo‐controlled trial evaluated the effects of live probiotic and HT postbiotic B. longum CECT 7347 in adults with moderate–severe allergic rhinitis. Postbiotic supplementation for 8 weeks significantly reduced CSMS and dSS, exceeding the established CSMS MCID with a 33% greater improvement, when compared to placebo ...
Ana Cardoso, Malwina Naghibi, Eric Climent, Andrea Rodenes‐Gavidia, Araceli Lamelas, Laura Llobregat, Juan Martínez‐Blanch, Daniel Friedman, Vineetha Vijayakumar, Richard Day   +9 more
wiley   +1 more source

Keratinocyte Priming by Staphylococcus aureus Reduces HSV‐1 Susceptibility

Allergy, EarlyView.
ADEH+ patients have a reduced microbial diversity with increased S. aureus and S. epidermidis colonization compared to ADEH− and healthy controls. Heat‐killed S. aureus reduced HSV‐1 susceptibility and release of infectious progeny virus in a keratinocyte in vitro model. Heat‐killed S.
Phila Cara Baumann, Rebecca Pospich, Katinka Döhner, Ilona Klug, Julio Cesar Villalvazo Guerrero, Jan Hartmann, Inken Harder, Wolfgang Lieb, Barbara Kind, Andreas Kleinheinz, Susanne Abraham, Matthias Augustin, Elke Weisshaar, Jochen Schmitt, Stephan Weidinger, Beate Sodeik, Thomas Werfel, Lennart M. Roesner, Stephan Traidl, The TREATgermany Study Group   +19 more
wiley   +1 more source

Serotonin Degradation and Lipid Metabolism Regulate Human Tc2 Cell Effector Functions

Allergy, EarlyView.
Human Tc2 cells exhibit a metabolically active phenotype characterized by enhanced glycolysis, mitochondrial respiration, and fatty acid uptake dependent on PPARγ. Alarmins strongly amplify IL‐5 and IL‐13 production in Tc2 cells, supporting a shared immunometabolic program across type 2 lymphocytes.
Sabrina de Souza Ferreira, Lisa Holla, Sophia Björkander, Marie Kaarup Bek, Lorenz Wirth, Patrick A. Shearer, Jesper Säfholm, Erik Sachs, Mamdoh Al‐Ameri, Kasra Vali, Sandra Ekström, Erik Melén, Jenny Mjösberg, Christopher Andrew Tibbitt   +13 more
wiley   +1 more source

Shotgun Metagenomics Reveals Skin Microbiome Composition and Function in Infant Atopic Disease

Allergy, EarlyView.
Deep shotgun metagenomics profiled > 1000 infant skin swabs in the VITALITY cohort. Distinct skin microbiome signatures separated AD alone from AD with allergic co‐occurrence. Early Staphylococcus enrichment preceded later AD with allergic co‐occurrence. FLG mutations and strain‐level analyses revealed host and microbial features linked to AD.
Zeyang Shen, Jana K. Eckert, Richard Saffery, Katrina J. Allen, Audrey Walsh, VITALITY team, Kirsten Perrett, Katrina J. Allen, Justin Brown, Natalie Carvalho, Nigel Curtis, Kim Daziel, Shyamali Dharmage, Ronda Greaves, Lyle Gurrin, Li Huang, Jennifer Koplin, Katherine Lee, Georgia Paxton, Rachel Peters, Anne‐Louise Ponsonby, Peter Sayre, Mimi Tang, Peter Vuillermin, Melissa Wake, Angela Young, Deborah Anderson, Christine Axelrad, Anna Bourke, Kirsty Bowes, Tim Brettig, Natasha Burgess, Beatriz Camesella‐Perez, Xueyuan Che, Daniela Ciciulla, Jac Cushnahan, Helen Czech, Thanh Dang, Kathryn Dawes, Jana Eckert, Hannah Elborough, Michael Field, Charlie Fink, Sarah Fowler, Grace Gell, Rebecca Gray, Emi Habgood, Richard Hall, Phoebe Harris, Erin Hill, Kensuke Hoashi, Hannah Ilhan, Narelle Jenkins, Andrew Knox, Clare Morrison, Melanie Neeland, Jenn Ness, Wendy Norton, Sasha Odoi, Mary Panjari, Kayla Parker, Ahelee Rahman, Ashleigh Rak, Maisie Ralphsmith, Natalie Schreurs, Carrie Service, Victoria Soriano, Judith Spotswood, Mark Taranto, Leone Thiele, Kate Wall, Audrey Walsh, Angela Walsh, Anita Wise, Andrew Davidson, Arul Earnest, Lara Ford, Andrew Kemp, Sam Mehr, Tibor Schuster, Dean Tey, Diana Zannino, Donna Legge, Jason Bell, Joanne Cheah, Kay Hynes, Kee Lim, Emily Porrello, Annette Powell, Pedro Ramos, Anushka Karunanayake, Izabelle Mezzetti, Kayla Parker, Ronita Singh, Harriet Edmund, Bridie Byrne, Tom Keeble, Cuby Martis, Belle Ngien, Penny Glenn, Andrew Kaynes, Clay Deming, Qiong Chen, Karen Laky, Jenny Min Li, Lindsay Chatman, NISC Comparative Sequencing Program, Beatrice B. Barnabas, Sean Black, Gerard G. Bouffard, Shelise Y. Brooks, Juyun Crawford, Holly Marfani, Lyudmila Dekhtyar, Joel Han, Shi‐Ling Ho, Richelle Legaspi, Quino L. Maduro, Catherine A. Masiello, Jennifer C. McDowell, Casandra Montemayor, James C. Mullikin, Morgan Park, Nancy L. Riebow, Karen Schandler, Brian Schmidt, Christina Sison, Sirintorn Stantripop, James W. Thomas, Pamela J. Thomas, Meghana Vemulapalli, Alice C. Young, Heidi H. Kong, Kirsten P. Perrett, Julia A. Segre, Pamela A. Frischmeyer‐Guerrerio   +135 more
wiley   +1 more source

T Cell Microenvironmental Impacts and Therapeutic Opportunities: Application to Human Testicular Germ Cell Tumors

Andrology, EarlyView.
ABSTRACT Testicular germ cell tumors (TGCT) are the leading malignancy in adolescent and young adult males, yet the immunological and cellular mechanisms governing their tumor microenvironment (TME) remain poorly understood. Here, we present a comprehensive review of TGCT pathobiology with a focus on the immune landscape, particularly the role of tumor‐
R Islam, M Figura, J Heyer, S Lieber, M Huber, KL Loveland, HC Schuppe, Daniela Fietz   +7 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

British Journal of Pharmacology, EarlyView.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown, Alan Armstrong, David J. Mann   +2 more
wiley   +1 more source

Re‐thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics

British Journal of Pharmacology, EarlyView.
Obesity is a chronic, relapsing, multisystem disease in which cardiometabolic risk arises from excess adiposity and progressive dysfunction of peripheral organs, ultimately disrupting endocrine and metabolic crosstalk among tissues. Within this network, sulphur‐based biology, centred on hydrogen sulphide and related reactive sulphur species, has ...
Martina Smimmo, Veronica Casale, Roberta d'Emmanuele di Villa Bianca, Valentina Vellecco, Mariarosaria Bucci   +4 more
wiley   +1 more source

Therapeutic potential of a Bax inhibitor‐1/TMBIM6 antagonist (BIA) and its analogues in Aspergillus fumigatus‐induced asthma via dual targeting of AKT and epithelial‐derived inflammatory cytokines

British Journal of Pharmacology, EarlyView.
Background and Purpose Aspergillus fumigatus (A. fumigatus) exposure causes of severe allergic asthma, characterized by airway inflammation and epithelial dysfunction. TMBIM6 (Bax inhibitor‐1) has been implicated in airway epithelial stress responses and AKT signalling.
Young‐Jin Yu, Ahsan Ullah, Jisun Kim, Mehedi Hasan Bappi, Yerim Heo, Jin Hee Ahn, Hyun‐Kyoung Kim, Han‐Jung Chae   +7 more
wiley   +1 more source

Discovery of functional PRRs for the fungal elicitor Xyn11/eix in Prunus fruit trees

Plant Stress
Pattern-triggered immunity (PTI) is a critical defense mechanism employed by plants against pathogen attacks. This study explores the role of PTI induced by the Xyn11/eix fungal elicitor in two commercially valuable Rosaceae species, Prunus persica ...
Andree Alvarez, Uri Aceituno-Valenzuela, Meirav Leibman-Markus, Daniela Muñoz, Carlos Rubilar, Franco Figueroa, Manuel Pinto, Mauricio Latorre, Claudia Stange, Adi Avni, Maya Bar, Lorena Pizarro   +11 more
doaj   +1 more source