Results 191 to 200 of about 6,492 (255)

Trained Immunity in Childhood Vaccination

open access: yesActa Paediatrica, Volume 115, Issue 11, Page 2402-2413, November 2026.
Trained immunity as an emerging concept in paediatric vaccinology. Trained immunity links vaccine stimuli through epigenetic and metabolic reprogramming to enhanced innate immune cell function, thereby strengthening protection against diverse pathogens while promoting adaptive immune responses through more efficient antigen presentation and co ...
ChenRongRong Cai   +2 more
wiley   +1 more source

Covalent drug discovery: Progress against key targets, emerging strategies and lessons learnt

open access: yesBritish Journal of Pharmacology, Volume 183, Issue 22, Page 6574-6606, November 2026.
Abstract Covalent drug discovery is currently experiencing a boom in industrial and academic interest. To date, at least 75 covalent drugs have received regulatory approval, targeting both traditional target classes and more challenging proteins for which other approaches failed. In many cases, unique aspects of covalent targeting are essential for the
Charles P. Brown   +2 more
wiley   +1 more source

Advances in Cytosolic dsRNA Sensing of Viral Infections

open access: yesImmunology &Cell Biology, Volume 104, Issue 10, Page 975-986, November‐December 2026.
Activation of cytosolic dsRNA sensors by viral infection generates multiple outcomes. dsRNA generated during viral infection, either of viral origin or from endogenous sources, can activate multiple cytosolic dsRNA sensors. Activation of PKR critically induces protein translation shutdown via phosphorylation of eukaryotic translation initiation factor ...
Sofia Maceratessi, Natalia G. Sampaio
wiley   +1 more source

Chitosan activates a sequential Ca <sup><b>2+</b></sup> -ROS-NO-jasmonate signaling cascade governing withanolide accumulation in <i>Withania somnifera</i>. [PDF]

open access: yesPlant Signal Behav
Perveen S   +8 more
europepmc   +1 more source

Towards an In‐Depth Understanding of the Versatile Functions of Silicon in Legumes Under Biotic and Abiotic Stress: Identifying Research Gaps

open access: yesJournal of Agronomy and Crop Science, Volume 212, Issue 6, November 2026.
ABSTRACT Studies have shown the vital role of silicon (Si) under stress conditions, suggesting it could be used as a basic fertilizer. Collectively, as a strategic approach under biotic and abiotic stress conditions, Si offers a sustainable means to boost legume resilience and productivity, thereby contributing significantly to food security amid ...
Muna A. Abdalla   +3 more
wiley   +1 more source

Assessing Zymoseptoria tritici Candidate Effectors in the Non‐Host Nicotiana benthamiana Reveals Immune Recognition and Potential Host‐Independent Activities

open access: yesMolecular Plant Pathology, Volume 27, Issue 11, November 2026.
To investigate effector functions in Zymoseptoria tritici, we transiently expressed seven candidate effectors in the non‐host Nicotiana benthamiana. Responses reflected a combination of immune recognition and potential conserved activities, and primarily serve to prioritize candidates for validation in the native wheat–Z. tritici interaction.
Sandra V. Gomez‐Gutierrrez   +5 more
wiley   +1 more source

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