Single-molecule real-time sequencing combined with optical mapping yields completely finished fungal genome [PDF]
mBio, 2015 Next-generation sequencing (NGS) technologies have increased the scalability, speed, and resolution of genomic sequencing and, thus, have revolutionized genomic studies.
Datema, Erwin +6 more
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The Dynamic Fungal Genome: Polyploidy, Aneuploidy and Copy Number Variation in Response to Stress. [PDF]
Annu Rev Microbiol, 2023 Fungal species have dynamic genomes and often exhibit genomic plasticity in response to stress. This genome plasticity often comes with phenotypic consequences that affect fitness and resistance to stress.
Vande Zande P, Zhou X, Selmecki A.
europepmc +2 more sources
G3: Genes, Genomes, Genetics, 2021 Transposable elements (TEs) impact genome plasticity, architecture, and evolution in fungal plant pathogens. The wide range of TE content observed in fungal genomes reflects diverse efficacy of host-genome defense mechanisms that can counter-balance TE ...
Cécile Lorrain +4 more
doaj +2 more sources
Advances and Challenges in CRISPR/Cas-Based Fungal Genome Engineering for Secondary Metabolite Production: A Review. [PDF]
J Fungi (Basel), 2023 Fungi represent an important source of bioactive secondary metabolites (SMs), which have wide applications in many fields, including medicine, agriculture, human health, and many other industries.
Wang D, Jin S, Lu Q, Chen Y.
europepmc +2 more sources
Telomere Roles in Fungal Genome Evolution and Adaptation. [PDF]
Front Genet, 2021 Telomeres form the ends of linear chromosomes and usually comprise protein complexes that bind to simple repeated sequence motifs that are added to the 3′ ends of DNA by the telomerase reverse transcriptase (TERT). One of the primary functions attributed
Rahnama M +17 more
europepmc +2 more sources
Plant and Fungal Genome Editing to Enhance Plant Disease Resistance Using the CRISPR/Cas9 System. [PDF]
Front Plant Sci, 2021 Crop production has been substantially reduced by devastating fungal and oomycete pathogens, and these pathogens continue to threaten global food security.
Paul NC +7 more
europepmc +2 more sources
High molecular weight DNA extraction methods lead to high quality filamentous ascomycete fungal genome assemblies using Oxford Nanopore sequencing. [PDF]
Microb Genom, 2022 During the last two decades, whole-genome sequencing has revolutionized genetic research in all kingdoms, including fungi. More than 1000 fungal genomes have been submitted to sequence databases, mostly obtained through second generation short-read DNA ...
Petersen C +6 more
europepmc +2 more sources
Discovery of fungal onoceroid triterpenoids through domainless enzyme-targeted global genome mining
Nature CommunicationsGenomics-guided methodologies have revolutionized the discovery of natural products. However, a major challenge in the field of genome mining is determining how to selectively extract biosynthetic gene clusters (BGCs) for untapped natural products from ...
Jia Tang, Yudai Matsuda
doaj +2 more sources
Advances in understanding the evolution of fungal genome architecture. [PDF]
F1000Res, 2020 Diversity within the fungal kingdom is evident from the wide range of morphologies fungi display as well as the various ecological roles and industrial purposes they serve.
Priest SJ, Yadav V, Heitman J.
europepmc +2 more sources
CRISPR-Cas for Fungal Genome Editing: A New Tool for the Management of Plant Diseases. [PDF]
Front Plant Sci, 2019 Fungal pathogens are the main factors responsible for the most severe diseases affecting plants, leading to significant reduction in yield and crop quality and causing enormous economic losses worldwide.
Muñoz IV +4 more
europepmc +2 more sources