Results 271 to 280 of about 1,539,097 (354)

Expanding the substrate scope of a bacterial monoterpene synthase for the production of sesquiterpenoid and diterpenoid products

The FEBS Journal, EarlyView.
We have converted the only known true bacterial monoterpene synthase, cineole synthase from Streptomyces clavuligerus (bCinS, C10 substrate), to a highly competent sesquiterpene synthase (C15) with a minimum number of rational mutations. By comparison with diterpene synthases (C20), we were then able to bestow diterpene synthase activity on bCinS. This
Nicole G. H. Leferink, Joshua N. Whitehead, Linus O. Johannissen, Nigel S. Scrutton   +3 more
wiley   +1 more source

Phosphate-solubilizing Bacillus subtilis Y31 promotes cucumber growth and yield: insights from rhizosphere microbiomics and bacterial genomics. [PDF]

Front Microbiol
Fu Y, Lin K, Cheng B, Qi L, Zhang Q, Li H, Chen X, Zhang C.   +7 more
europepmc   +1 more source

5-fluorocytosine resistance is associated with hypermutation and alterations in capsule biosynthesis in Cryptococcus [PDF]

, 2020
Billmyre, R. Blake, Clancey, Shelly Applen, Doering, Tamara L., Heitman, Joseph, Li, Lucy X.   +4 more
core   +1 more source

The structural, functional, and therapeutic potential of metacaspases in fungi and protozoa

The FEBS Journal, EarlyView.
Metacaspases are Ca2+‐dependent cysteine proteases whose structural characteristics, particularly calcium binding and autocatalytic processing, govern their activation and biological functions. These enzymes differ among microorganisms and regulate their cell cycles, making them excellent targets for drug development.
Ane C. M. Duarte, Mariana N. R. Trujilho, Karolaine S. S. M. Valdivia, Aline F. Araujo, Laura M. C. de Lorena, Vinicius H. de Oliveira, Beatriz V. Pereira, Emilly R. Leme, Wagner A. S. Júdice, Maurício F. M. Machado   +9 more
wiley   +1 more source

The poplar pathogen <i>Sphaerulina musiva</i> has a dynamic genome architecture marked by chromosomal inversions and changes in transposable element abundance. [PDF]

Microb Genom
Zaccaron AZ, Lassagne A, Søndreli KL, Sudermann MA, Alcalá Briseño RI, Grünwald NJ, Weisberg AJ, LeBoldus JM.   +7 more
europepmc   +1 more source

The First Whole Genome Sequencing of Historical Lichen Specimens Enables Genome‐Wide Analysis of Fungal and Algal Symbionts [PDF]

Mieko Kono, Yoshihito Ohmura, Yohey Terai   +2 more
openalex   +1 more source

Enzymatic synthesis of bioactive quinolones and (thio)coumarins by fungal type III polyketide synthases

The FEBS Journal, EarlyView.
Quinolones are valuable scaffolds for drug discovery but are rare in nature. Here, we show that two fungal enzymes, AthePKS and FerePKS, can generate 2‐quinolones and two additional heteroaromatic scaffolds. Using AthePKS, we designed an artificial enzymatic cascade towards an antimicrobial quinolone from a simple precursor and implemented it in E ...
Nika Sokolova, Angelina Osipyan, Lili Zhang, Matthew R. Groves, Sandy Schmidt, Kristina Haslinger   +5 more
wiley   +1 more source

Whole-genome sequencing and analysis of the symbiotic Mycena sp. L02 with Gastrodia Elata. [PDF]

BMC Genomics
Liu J, Su B, Miao J, Li S, Zhang Q, Wang F, Lin Y, Lin L.   +7 more
europepmc   +1 more source

The genome and stage‐specific transcriptomes of the carrot weevil, Listronotus oregonensis, reveal adaptive mechanisms for host specialisation and symbiotic interactions

Insect Molecular Biology, EarlyView.
Comprehensive genome and stage‐specific transcriptomes reveal 14,637 genes in Listronotus oregonensis, advancing genetic insights into a key agricultural pest. Compared with related species, L. oregonensis exhibits reduced chemoreceptor gene families but expanded detoxification gene clusters, reflecting its narrow host range and adaptability.
Dave T. Ste‐Croix, Annie‐Ève Gagnon, Benjamin Mimee   +2 more
wiley   +1 more source

The relationships among alkaloid concentration, endophyte mycelial concentration and host genetics in the tall fescue Epichloë symbiosis. [PDF]

BMC Genomics
Talamantes DR, Phillips C, Young C, Wallace JG.   +3 more
europepmc   +1 more source