Results 101 to 110 of about 413,546 (332)

The Dynamic Influence of Olorofim (F901318) on the Cell Morphology and Organization of Living Cells of Aspergillus fumigatus

Journal of Fungi, 2020
The first characterized antifungal in the orotomide class is olorofim. It targets the de novo pyrimidine biosynthesis pathway by inhibiting dihydroorotate dehydrogenase (DHODH).
Saskia du Pré, Mike Birch, Derek Law, Nicola Beckmann, Graham E. M. Sibley, Michael J. Bromley, Nick D. Read, Jason D. Oliver   +7 more
doaj   +1 more source

Intracranial fusarium fungal abscess in an immunocompetent patient: case report and review of the literature. [PDF]

, 2014
Introduction Fusarium spp is an omnipresent fungal species that may lead to fatal infections in immunocompromised populations. Spontaneous intracranial infection by Fusarium spp in immunocompetent individuals is exceedingly rare.
Cadden, Joseph, Commins, Deborah, Giannotta, Steven L, Lee, Brian, Peterson, Asa, Pham, Martin H, Zada, Gabriel   +6 more
core   +1 more source

Advanced Pharmaceutical Nanotechnologies Applied for Chinese Herbal Medicines

Advanced Science, EarlyView.
This review offers a comprehensive overview of pharmaceutical nanotechnology strategies to address limitations associated with the complex material basis and relative mild therapeutic efficacy of Chinese herbal medicines, and summarizes the advantages of these strategies.
Jiameng Li, Ya‐Li Zhang, Tong Jin, Zhaokui Jin, Mengliang Zhu, Guangchao Qing, Jinchao Zhang, Zhisen Wang, Yan Mu, Jin Li, Qian Hua, Xing‐Jie Liang   +11 more
wiley   +1 more source

Gut microbiota in HIV-pneumonia patients is related to peripheral CD4 counts, lung microbiota, and in vitro macrophage dysfunction. [PDF]

, 2019
Pneumonia is common and frequently fatal in HIV-infected patients, due to rampant, systemic inflammation and failure to control microbial infection. While airway microbiota composition is related to local inflammatory response, gut microbiota has been ...
Byanyima, Patrick, Chang, Emily, Davis, J Lucian, Fadrosh, Douglas W, Fong, Serena, Huang, Laurence, Kaswabuli, Sylvia, Lin, Din L, Lynch, Susan V, McCauley, Kathryn, Musisi, Emmanuel, Sanyu, Ingvar, Shenoy, Meera K, Worodria, William, Zawedde, Josephine   +14 more
core   +2 more sources

Abiotic Factors and Plant Communities Shape the Distribution of Soil Pathogenic Oomycetes in Chinese Grasslands

Advanced Science, EarlyView.
The continental‐scale study reveals that soil phosphorus strongly predicts the richness of soil pathogenic oomycetes in Chinese grasslands, while precipitation and plant species richness drive their absolute abundance; modeling predicts ≈42% of grassland areas may face elevated oomycete disease risk under future climate scenarios, especially in typical
Junsheng Ke, Chen Zhu, Peixi Jiang, Peng Zhang, Kui Hu, Yilin Dang, Yao Xiao, Mu Liu, Huiying Liu, Xiang Liu, Ville‐Petri Friman   +10 more
wiley   +1 more source

COVID-19 Therapeutics Use by Social Deprivation Index in England, July 2020–April 2023

COVID
Coronavirus disease-19 (COVID-19) has disproportionately affected certain demographics in England, exacerbating existing health disparities. Effective therapeutics are a critical line of defence against COVID-19, particularly for patients at elevated ...
Angela Falola, Hanna Squire, Sabine Bou-Antoun, Alessandra Løchen, Colin S. Brown, Alicia Demirjian   +5 more
doaj   +1 more source

Invasive fungal infections secondary to traumatic injury [PDF]

, 2017
Invasive fungal infection (IFI) is a rare but serious complication of traumatic injury. The purpose of this article is to review the epidemiology, natural history, mycology, risk factors, diagnosis, treatment, and outcomes associated with post-traumatic ...
Bochicchio, Grant, Bochicchio, Kelly, Kronen, Ryan, Liang, Stephen Y, Powderly, William G, Spec, Andrej   +5 more
core   +3 more sources

A Blast‐Resistant NLR Gene Confers Drought Resistance by Competitively Interacting with an E3 Ligase to Protect Phenylalanine Ammonia‐Lyase in Rice

Advanced Science, EarlyView.
The NLR protein PibH8 interacts with phenylalanine ammonia‐lyase OsPAL1 and E3 ubiquitin ligase OsFBK16. Through competitive binding, PibH8 weakens the interaction between OsFBK16 and OsPAL1, thereby reducing the degradation of OsPAL1 by OsFBK16. The Hap1 allele of PibH8 exhibits a higher expression level than Hap2, thus accumulating more PibH8 protein,
Denghao Xiang, Haifu Tu, Yang Yuan, Yilong Yao, Wanwen Liao, Huaijun Wang, Yu Yan, Yao Wang, Yu Chen, Di Liu, Qingya Lv, Haidong He, Honghong Hu, Xuelei Lai, Meng Yuan, Haiyan Xiong, Faming Dong, Lizhong Xiong   +17 more
wiley   +1 more source

Biofilm Inhibitory Abscisic Acid Derivatives from the Plant-Associated Dothideomycete Fungus, Roussoella sp.

Molecules, 2018
Roussoella species are well recorded from both monocotyledons and dicotyledons. As part of a research program to discover biologically active compounds from plant-associated Dothideomycetes in Thailand, the strain Roussoella sp.
Chayanard Phukhamsakda, Allan Patrick G. Macabeo, Kamila Tomoko Yuyama, Kevin David Hyde, Marc Stadler   +4 more
doaj   +1 more source

Freshwater Fungal Infections

Journal of Patient-Centered Research and Reviews, 2017
Fungal infections as a result of freshwater exposure or trauma are fortunately rare. Etiologic agents are varied, but commonly include filamentous fungi and Candida. This narrative review describes various sources of potential freshwater fungal exposure and the diseases that may result, including fungal keratitis, acute otitis externa and tinea pedis ...
openaire   +6 more sources