Results 61 to 70 of about 438,844 (285)

Pathogen-specific innate immune response patterns are distinctly affected by genetic diversity

open access: yesNature Communications, 2023
Innate immune responses vary by pathogen and host genetics. We analyze quantitative trait loci (eQTLs) and transcriptomes of monocytes from 215 individuals stimulated by fungal, Gram-negative or Gram-positive bacterial pathogens.
Antje Häder   +15 more
doaj   +1 more source

Aspergillus fumigatus ffmA Encodes a C2H2-Containing Transcriptional Regulator That Modulates Azole Resistance and Is Required for Normal Growth

open access: yesmSphere, 2022
The production of a collection of deletion mutant strains corresponding to a large number of transcription factors from the filamentous fungal pathogen Aspergillus fumigatus has permitted rapid identification of transcriptional regulators involved in a ...
Sanjoy Paul   +3 more
doaj   +1 more source

Invasive fungal infections [PDF]

open access: yesGERMS, 2012
2012, London. 22nd European Congress of Clinical Microbiology and Infectious Diseases (ECCMID). With over 300 million serious fungal infections worldwide, we need to be aware of the size of the problem (http://www.fungalresearch trust.org/HowCommonareFungalDiseases2.pdf) and the need for more diagnostic tools and treatment options. Given that the
openaire   +2 more sources

Antimicrobial Efficacy of a Taurolidine‐Based Antimicrobial Compound on Contaminated Surfaces Simulated in a Standardized 4‐Field Test

open access: yesAdvanced Healthcare Materials, EarlyView.
As implantable medical devices become indispensable to modern medicine, a silent threat grows alongside them: device‐associated infections. Despite decades of antibiotic innovation, infection rates keep climbing, costing lives and billions in healthcare expenses.
Benito Baldauf   +5 more
wiley   +1 more source

Factoring in the Complexity of the Cystic Fibrosis Lung to Understand Aspergillus fumigatus and Pseudomonas aeruginosa Interactions

open access: yesPathogens, 2020
Pseudomonas aeruginosa has long been established as the most prevalent respiratory pathogen in Cystic Fibrosis (CF) patients, with opportunistic infection causing profound morbidity and mortality.
Emily Beswick, Jorge Amich, Sara Gago
doaj   +1 more source

Novel Insights into Aspergillus fumigatus Pathogenesis and Host Response from State-of-the-Art Imaging of Host–Pathogen Interactions during Infection

open access: yesJournal of Fungi, 2022
Aspergillus fumigatus spores initiate more than 3,000,000 chronic and 300,000 invasive diseases annually, worldwide. Depending on the immune status of the host, inhalation of these spores can lead to a broad spectrum of disease, including invasive ...
Sébastien C. Ortiz   +3 more
doaj   +1 more source

Key Parameter Comparisons of Fungal Induced Mortality in Alfalfa Weevil Larvae (Coleoptera: Curculionidae) [PDF]

open access: yes, 2017
Key parameters of alfalfa weevil larval mortality by Entornophthora phytonorni were compared weekly in three alfalfa fields.
Armbrust, Edward J, Barney, Robert J
core   +3 more sources

Imported fungal infections [PDF]

open access: yesPostgraduate Medical Journal, 1979
Summary Data on mycoses known to be imported into the United Kingdom are sparse. Estimates on the prevalence of fungal infections have to be based on indirect and incomplete figures, obtained from isolation figures and reports of individual cases to co-ordinating centres such as the Mycological Reference Laboratory and the Communicable ...
openaire   +2 more sources

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

open access: yesAdvanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales   +11 more
wiley   +1 more source

Functional analysis of the Aspergillus fumigatus kinome identifies a druggable DYRK kinase that regulates septal plugging

open access: yesNature Communications
More than 10 million people suffer from lung diseases caused by the pathogenic fungus Aspergillus fumigatus. Azole antifungals represent first-line therapeutics for most of these infections but resistance is rising, therefore the identification of ...
Norman van Rhijn   +20 more
doaj   +1 more source

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