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Overcoming the Stromal Barrier of the Cornea with a Peptide Conjugate Nano‐Assembly to Combat Fungal Keratitis

Advanced Healthcare Materials, 2023
Fungal hyphae deeply invade the cornea in fungal keratitis. The corneal stroma hinders the infiltration of antifungal drugs and reduces their bioavailability.
Xiaoyan Ju   +8 more
semanticscholar   +1 more source

Visualized Gallium/Lyticase‐Integrated Antifungal Strategy for Fungal Keratitis Treatment

Advances in Materials, 2022
Fungal keratitis has been one of the common corneal infections that causes blindness, but an effective antifungal strategy remains a challenge. The exopolysaccharides both in the fungal cell walls and biofilms are a key that acts as a permeation barrier ...
Jian He   +4 more
semanticscholar   +1 more source

Cell Wall Destruction and Internal Cascade Synergistic Antifungal Strategy for Fungal Keratitis.

ACS Nano, 2022
Fungal keratitis is one of the most common blindness-causing diseases, but clinical antifungal treatment remains a challenge. The fungal cell wall and biofilm matrix which severely confine the drug preparation are the critical obstructive factors to ...
Yang Ye   +10 more
semanticscholar   +1 more source

Fungal keratitis

Journal Français d'Ophtalmologie, 2017
Fungal keratitis, or keratomycoses, are corneal infections which must be considered in cases of corneal trauma, prior corneal surgery, chronic ocular surface disease, topical corticosteroids or contact lens wear. Filamentous fungi or yeasts may be involved.
T, Bourcier   +4 more
openaire   +3 more sources

Clinical Outcomes of Rose Bengal Mediated Photodynamic Antimicrobial Therapy on Fungal Keratitis with Their Microbiological and Pathological Correlation

Current Eye Research, 2022
Purpose To report the clinical outcome of Photodynamic Antimicrobial Therapy (PDAT) with Rose Bengal (RB) used as an early adjuvant therapy in patients with fungal keratitis and their microbiological and pathological correlation.
Bhupesh Bagga   +5 more
semanticscholar   +1 more source

Flavopiridol Protects against Fungal Keratitis due to Aspergillus fumigatus by Alleviating Inflammation through the Promotion of Autophagy.

ACS Infectious Diseases, 2022
Fungal keratitis is a serious infectious keratopathy related to fungal virulence and excessive inflammatory responses. Autophagy exhibits a potent ability to resolve inflammation during fungal infection.
Lingwen Gu   +7 more
semanticscholar   +1 more source

Trichophyton Fungal Keratitis

Cornea, 2006
To report 5 cases of fungal keratitis caused by Trichophyton schoenleinii.Case reports.Trichophyton schoenleinii is responsible for aggressive fungal keratitis that is associated with keratolysis as a result of collagenase expression by the organism.
Michael D. Wagoner   +2 more
openaire   +3 more sources

Fungal keratitis in Melbourne

Clinical & Experimental Ophthalmology, 2007
AbstractBackground:  Description of the clinical and microbiological spectrum of fungal keratitis at a tertiary eye care hospital in Melbourne, Australia.Methods:  Retrospective review of all patients with keratitis with positive fungal cultures from corneal or associated samples presenting to the Royal Victorian Eye and Ear Hospital, Melbourne ...
Bhartiya, Prashant   +4 more
openaire   +4 more sources

Update on fungal keratitis

Current Opinion in Ophthalmology, 2016
The aim of this review article is to present an overview of some of the seminal work published in the last 18 months (July 2014 to December 2015).The published literature highlights the need for the identification of fungal isolates to species and subspecies level using molecular methods.
Sanhita Roy, Prashant Garg, Aravind Roy
openaire   +2 more sources

The challenge of fungal keratitis

British Journal of Ophthalmology, 2011
Worldwide corneal infections are a major cause of unilateral blindness.1 In some parts of the world, fungal infections are commoner than bacterial infections.2 3 The challenge lies not only in the diagnosis but also in appropriate therapy, once diagnosis is established.
Anusha Kailasanathan   +5 more
openaire   +3 more sources

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