Results 91 to 100 of about 729,622 (302)

A C‐Nucleoside Analogue of Cordycepin With High Metabolic Stability and Potent Anti‐Psoriatic Activity via Microneedle Delivery

Advanced Science, EarlyView.
This work identified CPD3a as a potent, stable C‐nucleoside cordycepin derivative. When formulated into microneedle array for topical treatment, it ameliorated psoriasis by rebalancing immunity and enhancing antioxidant defenses. ABSTRACT Psoriasis is a chronic inflammatory disorder characterized by immune dysregulation and epidermal hyperplasia ...
Wenfang Pan, Xinyue Shao, Yuanchen Zhong, Xujie Sun, Lixuan Yin, Zongyan He, Tianqun Lang, Yuanchao Xie   +7 more
wiley   +1 more source

Gene induction during plant-microbe interactions : the role of chitinases during fungal infection and the investigation of mycorrhiza-induced genes in the model plant "M. truncatula" [PDF]

, 2007
In this thesis, the model legume Medicago truncatula was used for research on plant-microbe interactions. Unlike most other plants, legumes are able to form two distinct root symbioses. Together with soil-borne fungi of the Glomeromycota, they form the
Feddermann Bühler, Nadja
core   +1 more source

Biological characteristics of Alternaria solani fungal pathogen [PDF]

BIO Web of Conferences
The Alternaria genus is found in various regions of the world. One economically significant member of this genus is Alternaria solani, which causes early blight disease in potatoes and tomatoes.
Yuldosheva Zebo, Sodikov Bakhrom, Khamirayev Ural, Makamov Abdusalom   +3 more
doaj   +1 more source

Chimeric IL‐6/4R‐LL37 Engineered Macrophages Achieve Synchronized Inflammation Control and Antimicrobial Defence in Sepsis

Advanced Science, EarlyView.
Engineered macrophages programmed in situ by LNP‐delivered IL‐6/4 fusion and LL37 mRNAs simultaneously dampen cytokine storm, promote M2‐like repair, and enhance direct bacterial killing in sepsis. This combinatorial strategy restores T cell and macrophage function, lowers organ bacterial burden, and improves survival, highlighting a precision, host ...
Tianyang Jie, Zheyu Zhang, Hao Zhang, Linke Bian, Penglong Zheng, Sijia Zhou, Minqi Wang, Mingyu Qu, Yufei Wang, Xinhua Qu, Bing Yue   +10 more
wiley   +1 more source

Development of Fungal Applications on Netting Substrates for Malaria Vector Control [PDF]

, 2011
Mosquito resistance to chemical insecticides is considered a serious threat for the sustainable use of contemporary malaria vector control methods.
Thomas, Matthew B., Knols, B.G.J., Hilhorst, Anne, Farenhorst, M., Farenhorst, Marit, Knols, Bart G. J., Hilhorst, A., Thomas, M.B.   +7 more
core   +1 more source

Landscape connectivity limits the predicted impact of fungal pathogen invasion [PDF]

, 2020
Infectious diseases are major drivers of biodiversity loss. The risk of fungal diseases to the survival of threatened animals in nature is determined by a complex interplay between host, pathogen and environment.
Pasmans, Frank, Frank Pasmans, An Martel, Bogaerts, S., Bayram Göçmen, Panayiotis Pafilis, Bogaerts, Sergé, Göçmen, Bayram, Lymberakis, P., Martel, An, Martel, A., Veith, Michael, Woeltjes, Tonnie, Li, Z., Michael Veith, Göçmen, B., Li, Zhimin, Pasmans, F., Pafilis, P., Zhimin Li, Petros Lymberakis, Tonnie Woeltjes, Pafilis, Panayiotis, Lymberakis, Petros, Sergé Bogaerts   +24 more
core   +1 more source

Protease‐Triggered Chromogenic Release From Peptide‐Modified Calcium Carbonate Microspheres Enables Colorimetric Detection of Porphyromonas gingivalis Activity

Advanced Science, EarlyView.
We report a chromogenic release‐based assay system with protease‐cleavage peptide‐modified calcium carbonate microspheres for colorimetric detection of Porphyromonas (P.) gingivalis activity. In response to Arg‐specific gingipain secreted by P. gingivalis, the supernatant becomes colored, enabling colorimetric analysis and providing the monitoring of ...
Yuki Hiruta, Zhicheng Jin, Mari Adachi, Lubna Amer, Natalia O. Tjokro, Diego F. Trujillo, Jan Potempa, Anthony J. O'Donoghue, Casey Chen, Jesse V. Jokerst   +9 more
wiley   +1 more source

Molecular mechanisms underlying tree host-pathogen interactions under drought stress and subsequent rewatering in Eucalyptus grandis

Plant Stress
Abiotic stresses such as drought change plant-pathogen interactions by affecting both hosts and pathogens. Here, we aimed to unravel the molecular mechanisms underlying forest tree-pathogen interactions under drought stress and subsequent rewatering.
Demissew Tesfaye Teshome, Godfrey Elijah Zharare, Raphael Ployet, Sanushka Naidoo   +3 more
doaj   +1 more source

A CRISPR Interference Platform for Efficient Genetic Repression in Candida albicans

mSphere, 2019
Fungal pathogens are emerging as an important cause of human disease, and Candida albicans is among the most common causative agents of fungal infections.
Lauren Wensing, Jehoshua Sharma, Deeva Uthayakumar, Yannic Proteau, Alejandro Chavez, Rebecca S. Shapiro   +5 more
doaj   +1 more source

Pathogenic Roles for Fungal Melanins [PDF]

Clinical Microbiology Reviews, 2000
SUMMARY Melanins represent virulence factors for several pathogenic fungi; the number of examples is growing. Thus, albino mutants of several genera (in one case, mutated precisely in the melanizing enzyme) exhibit decreased virulence in mice.
openaire   +2 more sources