Results 231 to 240 of about 148,570 (344)

Comprehending the Membrane Properties for Emulation in Organs‐on‐a‐Chip

open access: yesAdvanced NanoBiomed Research, EarlyView.
The advent of organ‐on‐chip models allows closer emulation of in vivo conditions, leading to effective, less costly, and specific drugs. Although a number of membrane‐based on‐chip models exist, better emulating functional models need to be devised for organ simulations.
Tanmayee Makarand Sathe   +1 more
wiley   +1 more source

Substrate‐Selective Temperature‐Controlled Synthesis of Thiophene Derivatives at Interfaces

open access: yesAngewandte Chemie, EarlyView.
The deposition of a dithiophene derivative on Ag(111) at room temperature followed by annealing gives rise to molecular wires, whereas the adsorption of the same precursor on a hot substrate affords the formation of benzotrithiophene species. Abstract The temperature‐controlled transformation of organic molecules at interfaces is an incipient yet ...
Elena Pérez‐Elvira   +16 more
wiley   +2 more sources

Combined Delivery of CuO Nanoparticles and HIF‐1α Inhibitor Acriflavine for Synergistic Local Treatment of Glioblastoma

open access: yesAdvanced NanoBiomed Research, EarlyView.
Encapsulated acriflavine (ACF) and copper oxide nanoparticles (CuO NPs) are coreleased from coaxial nanofibers, producing synergistic antiglioblastoma multiforme effects. ACF suppresses the hypoxia‐inducible factor 1α pathway related to many downstream factors for tumor growth, while CuO NPs generate reactive oxygen species that assist cuproptosis ...
Daewoo Han   +4 more
wiley   +1 more source

Caylobolide B: Structure Revision, Total Synthesis, Biological Characterization, and Discovery of New Analogues

open access: yesAngewandte Chemie, EarlyView.
Marine polyhydroxylated macrolides’ drug discovery potential is limited by structural complexity and scarce material supply, hindering structure assignment, synthesis, and biological studies. Here, we present an integrated workflow that combines chemogenomic profiling, ultra‐high‐resolution NMR‐guided structural revision and stereochemical assignment ...
Malcolm R. P. George   +9 more
wiley   +2 more sources

Surface‐Coated Inorganic Nanomaterials for Drug Delivery: Chemical Design, Biomedical Applications, and Mechanistic Insights

open access: yesAdvanced NanoBiomed Research, EarlyView.
This review explores how surface‐coated inorganic nanomaterials are chemically engineered for advanced drug delivery. It highlights design principles, coating strategies, and biomedical applications, emphasizing how surface chemistry governs biocompatibility, targeting, and controlled release.
Hossein Daneshgar   +4 more
wiley   +1 more source

Sclerotinia sclerotiorum growth and aggressiveness are regulated by a mycoviral REP protein. [PDF]

open access: yesPLoS Pathog
Shu P   +12 more
europepmc   +1 more source

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