Results 201 to 210 of about 1,814,201 (243)

Hydroxamic Acids as HDAC Inhibitor Drug Leads for Malaria

Medicinal Research Reviews, EarlyView.
ABSTRACT Malaria is a global health threat, with an estimated 282 million cases and 610,000 malaria‐associated deaths reported in 2024. Most mortality is due to infection by Plasmodium falciparum parasites, with the highest burden occurring in Sub‐Saharan Africa.
Wisam A. Dawood, Jacinta R. Macdonald, Christian Anzenhofer, Tina S. Skinner‐Adams, Robert C. Reid, Thomas Kurz, David P. Fairlie, Katherine T. Andrews   +7 more
wiley   +1 more source

Artificial Intelligence‐Driven Natural Product Drug Discovery: From Computational Genome Mining to Clinical Translation

Medicinal Research Reviews, EarlyView.
ABSTRACT Natural products (NPs) have historically yielded numerous therapeutic agents, yet their integration into modern drug discovery has been constrained by chemical complexity, low abundance, laborious dereplication, and limited target annotation.
Antonio Lavecchia
wiley   +1 more source

Image‐Derived Volumetry During Forced Expiration Using a 3D Fermat Looped, Orthogonally Encoded Trajectory

Magnetic Resonance in Medicine, EarlyView.
ABSTRACT Purpose To enable MRI‐based nongated 3D depiction of forced expiration with both high spatio‐temporal resolution and fidelity of lung dynamics. Methods An undersampled 3D Fermat looped, orthogonally encoded trajectory (FLORET) was optimized for nonsegmented dynamic acquisitions during forced expiration and a corresponding model‐based ...
Sebastian Scheidel, Viktor Hartung, Matthias Stephan Anders, Corona Metz, Herbert Köstler, Simon Veldhoen, Tobias Wech   +6 more
wiley   +1 more source

Deciphering plant–pathogen interaction with single‐cell omics

New Plant Protection, EarlyView.
Recent advances in single‐cell omics have enabled the decoding of gene regulatory networks at the cellular resolution during pathogen challenge. This review summarizes the technological developments in plant single‐cell omics and highlights their unique advantages for dissecting nearly all stages of plant–pathogen interactions, including initial ...
Lu Gan, Wenwen Liu, Syed S. Zaidi, Huaibing Jin   +3 more
wiley   +1 more source

Thioredoxin and Glutaredoxin Systems Required for Oxidative Stress Resistance, Fungicide Sensitivity, and Virulence of Alternaria alternata. [PDF]

Appl Environ Microbiol, 2018
Ma H, Wang M, Gai Y, Fu H, Zhang B, Ruan R, Chung KR, Li H.   +7 more
europepmc   +1 more source

Impact of the GouM transporter on secondary metabolism activation and production yield in Streptomyces noursei strain CK‐15

New Plant Protection, EarlyView.
Overexpression of the gouM transporter gene in Streptomyces noursei CK‐15 enhances gougerotin production by 114% and activates silent biosynthetic gene clusters. This finding links transporter activity to metabolite efflux and secondary metabolism, offering a strategy for natural product discovery and strain optimization.
Qianying Zhou, Hua Yu, Rouhallah Sharifi, Muhammad Usman, Shun Lai Ei, Abdel‐Hamied M. Rasmey, Beibei Ge   +6 more
wiley   +1 more source

Efficacy of Endoscopic Sinus Surgery for Allergic Fungal Rhinosinusitis: A Systematic Review With Meta‐analysis

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Endoscopic sinus surgery (ESS) plays a central role in the management of allergic fungal rhinosinusitis (AFRS); however, outcomes vary across studies. The goal of this study is to systematically review and synthesize evidence on the outcomes of ESS in patients with AFRS.
Amani Kais, Jad Kfouri, Ahmad R. Sedaghat, Charles Alex Riley, Chadi A. Makary   +4 more
wiley   +1 more source

Structural and Rheological Properties of Chitosan‐Biochar Composites Prepared With Waste Biomass‐Derived Biochar

Polymer Engineering &Science, EarlyView.
Chitosan dispersions containing biochar derived from vine pruning residue showed increasing shear stress and improved thermal stability with loading. Flow behavior was described by the Bingham plastic model in all cases. These results support the valorization of agricultural waste in functional biopolymer formulations.
Ahmet Eser, Mehmet Sadrettin Zeybek, Mertcan Öksüz, Kamil Şirin   +3 more
wiley   +1 more source

Advancing Sclerotinia risk forecasting for winter rapeseed in Germany: integrating crop phenology and disease development into a decision support system

Pest Management Science, EarlyView.
Integrating crop phenology and sclerotia germination models into SkleroPro improved Sclerotinia risk prediction accuracy from 34% to 66%, optimizing fungicide timing and supporting sustainable winter rapeseed production. Abstract BACKGROUND Sclerotinia stem rot, caused by Sclerotinia sclerotiorum, threatens winter rapeseed (Brassica napus) production ...
Vera Krause, Nazanin Zamani‐Noor, Lena Müller, Hella Kehlenbeck, Anto Raja Dominic   +4 more
wiley   +1 more source

Sensitivity of Irish Pyrenopeziza brassicae populations to methyl benzimidazole carbamate (MBC), quinone outside inhibitor (QoI) and succinate dehydrogenase inhibitor (SDHI) fungicides

Pest Management Science, EarlyView.
For three collections of Irish Pyrenopeziza brassicae populations fungicide sensitivity status to methyl benzimidazole carbamate (MBC), quinone outside inhibitor (QoI) and succinate dehydrogenase inhibitor (SDHI) fungicides was determined using sensitivity screening in vitro. Molecular mechanisms of insensitivity have been identified for MBC and QoI in
Diana E Bucur, Yong‐Ju Huang, Bruce DL Fitt, Steven Kildea   +3 more
wiley   +1 more source