Results 121 to 130 of about 981,244 (354)

A Hydrodynamic Bioreactor for High‐Yield Production of Extracellular Vesicles from Stem Cell Spheroids with Defined Cargo Profiling

Advanced Science, EarlyView.
This study harnesses hydrodynamic flows to generate, confine and stimulate stem cell spheroids, enabling the large‐scale production of extracellular vesicles (EVs). This innovative method not only streamlines spheroid formation and subsequent EV release in a single, integrated process, but also ensures the generation of EVs with enhanced biological ...
Solène Lenoir, Elliot Thouvenot, Giacomo Gropplero, Léonie Dec, Damarys Loew, Clotilde Théry, Jose E Perez, Claire Wilhelm   +7 more
wiley   +1 more source

Soybean Auxin Transporter PIN3 Regulates Nitrate Acquisition to Improve Nitrogen Use and Seed Traits

Advanced Science, EarlyView.
Xu et al. discovers that switching off auxin transporters in soybean, PIN3a and PIN3b, disrupts auxin flow; this triggers ARF‐STF3/4 signal cascade to activate the nitrate importer NPF2.13 and soil nitrogen acquisition. Multi‐year field trials show edited soybeans maintain yield with higher oil content, offering a potential genetic route to improve ...
Huifang Xu, Shiyu Huang, Jie Wang, Tian Wang, Qingqing Han, Kexin Wu, Zhen Gao, Xiaolei Shi, Tianli Tu, Ming Wang, Laimei Huang, Jiaomei Chen, Yunqi Liu, Yumei Zhang, Guoqiang Lin, Zhichang Chen, Xu Chen   +16 more
wiley   +1 more source

WS18.2 Using funnel plots to make meaningful centre comparisons

Journal of Cystic Fibrosis, 2015
Objectives The UK CF Registry annual reports include comparisons between centres on key outcomes such as FEV 1 using rankings. While illustrating the distribution between centres, they promote the assumption that those with the highest measures provide "better" care.
L. Pierotti, M.A. Mohammed, M. Wildman, D. Bilton, J. Boote, S.B. Carr, P. Cullinan, C. Elston, S. Harrison, J. Allen, P. Norman, S.J. MacNeill   +11 more
openaire   +1 more source

The Role of Antimatter Searches in the Hunt for Supersymmetric Dark Matter

, 2004
We analyze the antimatter yield of supersymmetric (SUSY) models with large neutralino annihilation cross sections. We introduce three benchmark scenarios, respectively featuring bino, wino and higgsino-like lightest neutralinos, and we study in detail ...
, , , , , Adriani O (Pamela Collaboration), Aprile E, Baer H Paige F E Protopopescu S D Tata X, Baltz E A, Baltz E A, Bergström L, Bergström L, Bernabei R, Boehm C, Bottino A, Catena R Fornengo N Masiero A Pietroni M Rosati F, Cesarini A, Chattopadhyay U Roy D P, Degrassi G, Desai S, Diehl E, Donato F, Donato F, Edsjö J, Edsjö J, Edsjö J Schelke M Ullio P, Feng J L, Feng J L, Ferreira P G, Fisk L A, Ghez A M, Giudice G F, Gondolo P Edsjö J Ullio P Bergström L Schelke M Baltz E A, Habig A, Hagiwara K, Hall L J, Hooper D, Hooper D Dingus B, Jeannerot R, Kamionkowski M, Klypin A, Mayer-Hasselwander H A, Picozza P, Pohl M, Profumo S, Profumo S, Profumo S Ullio P, Salati P, Sjöstrand T, Ullio P, Ullio P   +50 more
core   +1 more source

Bio‐Based Wax Interfaces for Droplet Energy Harvesting at Fluoropolymer‐Like Output Levels

Advanced Science, EarlyView.
Replacing unsustainable fluorinated polymers in droplet‐based energy harvesters is usually limited by low power outputs, but carefully selected bio‐based polymers are capable of creating fluoropolymer‐like voltage outputs. Abstract Droplet impact and rebound on solid surfaces has emerged as a promising method for energy harvesting, typically ...
Behnam Kamare, Mahla Shahabi, Matteo Carpi de Resmini, Tiago Fernandes, Fabian Meder   +4 more
wiley   +1 more source

Unveiling the diagnostic power of lncRNAs in colorectal cancer: a meta-analysis

BioMedical Engineering OnLine
Background Colorectal cancer (CRC) is a highly aggressive and extensive malignancy. Although long noncoding RNAs (lncRNAs) are often used as diagnostic biomarkers, their diagnostic effectiveness in CRC remains uncertain.
Wen Chen, Xinliang Liu, Zhenheng Wu, Haifen Tan, Fuqian Yu, Dongmei Wang, Xiaodan Lin, Zhigang Chen   +7 more
doaj   +1 more source

Global General Relativistic Magnetohydrodynamic Simulations of Accretion Tori

, 2003
This paper presents an initial survey of the properties of accretion flows in the Kerr metric from three-dimensional, general relativistic magnetohydrodynamic simulations of accretion tori.
Hawley J. F., Jean‐Pierre De Villiers, John F. Hawley, Krolik J. H., Paczynski B., Papaloizou J. C. B.   +5 more
core   +1 more source

Mendelian Randomization and Double Machine Learning Modeling Reveal Brain Imaging‐Derived Phenotypes as Functional Contributors to 18 Autoimmune Inflammatory Diseases

Advanced Science, EarlyView.
This schematic integrates the eight statistically significant causal relationships identified between 1,366 brain imaging‐derived phenotypes (IDPs) and 18 autoimmune inflammatory diseases (AIDs). Arrows indicate the direction of causality inferred from bidirectional two‐sample MR analyses.
Jinbin Chen, Xin Wang, Haifeng Ding, Bosheng Zheng, Keni Zeng, Chuying Hu, Jiayi Liu, Xiao Zhu, Haibing Yu   +8 more
wiley   +1 more source

Supplementary Figure S1. Funnel plots of studies on circulating CRP concentration and breast cancer risk from Circulating C-Reactive Protein and Breast Cancer Risk—Systematic Literature Review and Meta-analysis of Prospective Cohort Studies

, 2023
Doris S.M. Chan, Elisa V. Bandera, Darren C. Greenwood, Teresa Norat   +3 more
openalex   +2 more sources

From Sample to Mixed Reality: A Translational 3D MALDI Imaging Platform for Advanced 3D Spatial Omics Analysis of 3D Cell Culture Disease Models

Advanced Science, EarlyView.
A comprehensive technology platform enables high‐fidelity, volumetric MALDI imaging of 3D cell cultures by integrating custom embedding molds, a semi‐automated computational framework for 3D reconstruction, voxel‐instead of pixel‐based biomarker discovery, and immersive mixed reality data exploration.
Stefania Alexandra Iakab, Jonas Cordes, Thomas Enzlein, Florian Keller, Kevin Kastner, Theresa Mulholland, Björn Christian Fröhlich, Lars Gruber, James Lucas Cairns, Stefan Schmidt, Mathias Hafner, Richard Schneider, Johannes Betge, Frank Fischer, Julian Reichwald, Rüdiger Rudolf, Carsten Hopf   +16 more
wiley   +1 more source