Results 31 to 40 of about 2,534 (252)

Two-stage approach for class II mandibular furcation defect with insufficient keratinized mucosa: a case report with 3 years’ follow-up

Journal of International Medical Research, 2021
Periodontal regenerative treatment is useful for intrabony defects and furcation involvement, but is difficult when there is insufficient keratinized mucosa to cover and maintain the regenerative material, particularly in the mandibular molar region.
Hiroyuki Saida, Shunsuke Fukuba, Takahiko Shiba, Keiji Komatsu, Takanori Iwata, Hiroshi Nitta   +5 more
doaj   +1 more source

Reviving Furcation: Hyaluronic Acid and Xenograft for Grade II Defects

Journal of Multidisciplinary Dental Research
Furcation involvement in periodontal therapy, particularly in molars, is challenging, and conventional treatments often yield suboptimal results. Advances in understanding inflammation have led to exploring extracellular matrix (ECM) components like
A K Aysha Safoora, Krishnaraj Ganeshnarayanan, K B Uthappa, Rashmi S Pattanshetty   +3 more
doaj   +1 more source

Guided tissue regeneration and platelet rich growth factor for the treatment of Grade II furcation defects: A randomized double-blinded clinical trial - A pilot study

Dental Research Journal, 2017
Background: The treatment of furcation area defects remained as a challenging issue in periodontal treatments. Regeneration treatment of furcation defects is the most discussed periodontal treatment.
Niloofar Jenabian, Sina Haghanifar, Hodis Ehsani, Ehsan Zahedi, Masumeh Haghpanah   +4 more
doaj   +1 more source

Comparative analysis of various forms of local drug delivery systems on a class 2 furcation – A systematic review

Journal of Pharmacy and Bioallied Sciences, 2023
Class II mandibular furcation defect is a periodontal condition characterized by a cul-de-sac lesion, a definite parallel constituent with only a portion of alveolar bone remaining intact. There may be involvement of vertical bone loss.
Rishabh Kumar Das, V V Bharathwaj, R Sindhu, D Prabu, M Rajmohan, Dinesh Dhamodhar, S Sathiyapriya   +6 more
doaj   +1 more source

Calcium sulfate: An unconventional bone graft in the management of furcation involvement – A case series

Journal of International Clinical Dental Research Organization, 2019
This case series is an attempt to evaluate the potentials of calcium sulfate as a regenerative modality in the treatment of furcation involvement.
Mukherji Arnav
doaj   +1 more source

Classification of Furcation Involvement - A Literature Review

International Journal of Research and Review, 2022
Inflammatory periodontal disease, if unabated, ultimately progresses to attachment loss sufficient to affect the bifurcation or trifurcation of multirooted teeth. In multi-rooted teeth, the bone destruction can reach the area of root separation, thus exposing it to microbial colonization. In this occurrence, a “furcation involvement” is created.
Dr. Aishwarya Patil, Dr. Sarika Shetty
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Accuracy of Cone Beam Computed Tomography in the Assessment of Mandibular Molar Furcation Defects

Pesquisa Brasileira em Odontopediatria e Clínica Integrada, 2022
Objective: To evaluate the accuracy of cone-beam computed tomography (CBCT) in the assessment of mandibular molar furcation defects. Material and Methods: Thirty patients with furcation defects were selected, oral hygiene instructions, scaling, and root
Abdalwhab Alzwiri, Hesham Shokry Ismail, Santosh R. Patil   +2 more
doaj  

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source