Results 41 to 50 of about 302 (208)
Cysteine Thioaldehydes: Photolytic Generation, Reactivity, and Biological Implications
Angewandte Chemie, EarlyView.Photolysis of cysteine phenacylsulfides bearing non‐conjugating electron‐withdrawing substituents leads to high conversions into cysteine thioaldehydes through a Norrish type‐II pathway. This methodology enabled the study of the aqueous reactivity of these important biosynthetic intermediates, which, depending on peptide sequence, pH and buffer ...
Ardra Karthika +9 more
wiley +2 more sources
A culpa do chefe Atrida: uma abordagem no Agamémnon de Séneca
Classica, Revista Brasileira de Estudos Clássicos, 2016 Pretende este artigo centrar-se em alguns aspetos que envolvem a figura de Agamémnon na tragédia homónima de Séneca, tanto no plano temático como no plano simbólico, abarcando a questão da dimensão hereditária do crime, a morte de Ifigénia e a ligação do
Alexandra Coelho dos Santos
doaj +1 more source
Cell‐Selective Delivery of RIBOTACs via an Anti‐EGFR Nanobody for Pancreatic Cancer Treatment
Advanced Science, EarlyView.This study introduces an innovative strategy for the tumor‐selective catalytic degradation of oncogenic non‐coding RNA by interfacing a ribonuclease‐recruiting small molecule (RIBOTAC) with an EGFR‐targeting nanobody via a CTSB (Cathepsin B)‐responsive linker.
Tianli Luo +15 more
wiley +1 more source
Generation of the Camptothecin Scaffold by a Flavin‐Catalyzed Photooxidative Skeletal Reorganization
Angewandte Chemie, EarlyView.The biosynthetic pathway of the anticancer drug precursor camptothecin involves an enigmatic skeletal reorganization from a 6/5/6 tetrahydro‐β‐carboline to a 6/6/5 pyrroloquinoline ring system. Here, we show that this transformation can be achieved by photooxidation with flavin cofactors, such as flavin mononucleotide (FMN) as catalysts.
Shenyu Liu +6 more
wiley +2 more sources
O drama dos Atridas. A tragédia Thyestes de Séneca
Ágora, 2004 Faz-se uma leitura da tragédia senequiana Thyestes, à luz da análise estilística e ideológica de passos representativos. A expressão retórica e poético-dramática, em torno de palavras-chave, de áreas semânticas que o autor quer vincar, de forma ...
Nair de Nazaré Castro Soares
doaj +1 more source
Engineering‐Modulated Molybdenum Enzymes Strategy for Tumor‐Specific Metabolic‐Immunotherapy
Advanced Science, EarlyView.Biodegradable molybdenum sulfide nanoparticles were synthesized via a one‐pot strategy to increase molybdenum enzyme activity and thus effectively potentiate anti‐tumor immunity by integrating molybdenum‐based metalloimmunotherapy with hydrogen sulfide gas therapy.
Xiaoxiao Pan +14 more
wiley +1 more source
Flavin Catalysts in Organic Synthesis
Angewandte Chemie, EarlyView.Flavins and their congeners are potent catalysts for organic synthesis inspired by enzymatic transformations. In addition to catalysis in the flavin ground state via covalent intermediates, the excited singlet and triplet states unlock applications including photooxidation, photoreduction, and energy transfer via sensitization.
Jan Freudenberg, Golo Storch
wiley +2 more sources
Аграрная наука Евро-Северо-Востока, 2016 Humic preparations extracted from peat enhance resistance of living organisms against infections, stresses, cut rehabilitation period down, decrease risk for negative after-effects of vaccination. These preparations are not toxic, do not have cumulative,
V. V. Isaev, O. A. Burova, A. A. Blokhin
doaj
Compact 9dBEs Enable Efficient and Precise Genome Editing in Mammalian Cells and In Vivo
Advanced Science, EarlyView.As a compact type II‐D system, the Cas9d‐based platform holds great potential for in vivo applications. Through rational engineering, its derived base editors (9dBEs) enable efficient disease modeling while facilitating single‐vector AAV delivery for in vivo genome editing. These miniature tools offer a robust strategy for basic research and biomedical
Qingquan Xiao +12 more
wiley +1 more source
Ainda interpretamos crianças à maneira de Melanie Klein?
Estilos da Clínica, 2012 Este artigo pretende tratar dos principais aspectos do método clínico e interpretativo de Melanie Klein, das críticas mais contundentes que recebeu e, pela pertinência delas, do relativo distanciamento ocorrido entre a rígida postura de Klein e aquela ...
Nívea de Fátima Gomes +1 more
doaj +1 more source