Results 91 to 100 of about 19,556,327 (384)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

The impact of simulation-based training in medical education: A review

Medicine
Simulation-based training (SBT) has emerged as a transformative approach in medical education, significantly enhancing healthcare professionals’ learning experience and clinical competency.
Chukwuka Elendu, Dependable C. Amaechi, Alexander U Okatta, Emmanuel C. Amaechi, T. C. Elendu, Chiamaka P. Ezeh, Ijeoma D. Elendu   +6 more
semanticscholar   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Nurturing youth film literacy: Post-qualitative arts-based inquiry into critical self-awareness

The Journal for Transdisciplinary Research in Southern Africa
Post-digital, as a timeframe set, raises specific concerns for young adults engaged in artistic and cultural activities, seeking to establish a sustainable livelihood within a semi-rural South African context. They grapple with issues such as determining
Wendy Smidt, Zayd Waghid
doaj   +1 more source

Returns to investment in education: a further update

, 2002
Returns to investment in education based on human capital theory have been estimated since the late 1950s. In the 40‐plus year history of estimates of returns to investment in education, there have been several reviews of the empirical results in ...
G. Psacharopoulos, Harry Anthony Patrinos *   +1 more
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

The association of cytokine gene polymorphisms with the development and course of COVID-19

Журнал инфектологии
Objective: to study polymorphic variants of IL-2 (T330G), IL-10 (A592C), IL-6 (rs180795), INF a/b receptor (rs9984273), INFL4 (rs368234815), INFL3 (rs12979860), INF-γ (rs2430561) genes in COVID-19 patients to determine the risk of development and ...
N. I. Baranova, L. A. Ashchina, O. A. Kulieva, A. I. Bolgova   +3 more
doaj   +1 more source

Acute upper respiratory tract infections in children: antibiotic therapy

Медицинский совет, 2018
This article provides an overview of the current clinical guidelines and consensus papers on the role of bacterial infection, indications and algorithm for antibiotic therapy in the treatment of the most common acute upper respiratory tract infections in
D. A. Tulupov, E. P. Karpova
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source